耐辐射奇球菌DNA损伤响应开关蛋白PprI的研究进展  

Research Progress of the General Switch Protein Ppr I for DNA Damage Response in Deinococcus radiodurans

作　　者：黎婷婷[1] 王梁燕[1] 王云光[1] 华跃进[1] 

机构地区：[1]浙江大学原子核农业科学研究所/农业部核农学重点实验室,浙江杭州310029

出　　处：《核农学报》2016年第6期1106-1110,共5页Journal of Nuclear Agricultural Sciences

基　　金：国家自然科学基金(31210103904;31370102;31570058);国家重点基础研究发展计划(2015CB910600)

摘　　要：耐辐射奇球菌是迄今为止发现的最具辐射抗性的生物之一。其体内的Ppr I蛋白在整个DNA辐射损伤修复过程中起着必不可少的作用,ppr I作为一个细胞全局性的开关基因,协调控制DNA损伤响应与修复过程中众多细胞通路的基因表达。本文探讨了Ppr I在耐辐射奇球菌抗辐射和抗氧化中的生物学功能、相关结构功能以及对其他原核及真核生物抗逆性的影响,并展望了其潜在的生物学新功能与意义,旨在为进一步研究耐辐射奇球菌的辐射抗性机制提供理论依据。Deinococcus radiodurans is one of the most radio-resistant organisms discovered so far. PprI, a protein which was found in Deinococcus radiodurans plays an indispensable role in the processes of DNA damage repair, it also acts as a general switch to orchestrate the expression of a number of DNA damage response （DDR） proteins which involved in numerous cellular pathways. To provide theoretical basis for further study on the mechanism of Deinococcus radiodurans＇ radiation resistance. The biological functions of PprI in radio-resistance and anti-oxidation, its structure function and effects on stress resistance in other prokaryotic and eukaryotic organisms were discussed, the prospect of its novel potential function and significance.

关 键 词：耐辐射奇球菌 PPRI DNA损伤响应与修复 抗逆性 

分 类 号：Q93[生物学—微生物学]