SpO_2、GCS评分和血清乙酰胆碱酯酶与急性有机磷中毒病情和预后的关系分析  

Relationship between the SpO_2,GCS Score and Serum Cholinesterase of Acute Organophosphate Poisoning with the Illness Serenity and Prognosis

作　　者：黄寿新[1] 徐招柱[1] 

机构地区：[1]广东省梅州市人民医院EICU,514031

出　　处：《岭南急诊医学杂志》2016年第2期110-112,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨经皮血氧饱和度(SpO_2)、格拉斯哥昏迷指数(GCS)和血清乙酰胆碱酯酶(Ach E)与急性有机磷中毒(AOPP)病情和预后的关系。方法:以2012年6月至2015年6月我科收治的中毒后24 h内入院的AOPP患者76例为研究对象,比较半个月存活和死亡患者的SpO_2、GCS评分、血清Ach E水平和APACHEⅡ评分及其相关性。结果:与治疗前比较,治疗后的SpO_2、GCS评分和血清Ach E水平均明显升高,APACHEⅡ评分明显下降(P<0.05)。76例AOPP患者半个月死亡率为6.6%,且死亡患者的SpO_2、GCS评分和血清Ach E水平低于存活患者,APACHEⅡ评分则高于存活患者(P<0.05)。AOPP患者SpO_2、GCS评分和血清Ach E水平与其APACHEⅡ评分均呈负相关(r=-0.858,-0.842,-0.835,P<0.05),血清Ach E水平与其APACHEⅡ评分则呈正相关(r=0.826,P<0.05)。AOPP患者SpO_2、GCS评分和血清Ach E水平与其半个月死亡率均呈负相关(r=-0.879,-0.891,-0.852,P<0.05)。结论 :AOPP患者的SpO_2、GCS评分和血清Ach E水平低而APACHEⅡ评分和半个月病死率较高,其昏迷程度、缺氧程度和病情严重,预后情况差,且其SpO_2、GCS评分和血清Ach E水平与其病情和预后均相关,SpO_2、GCS评分和血清Ach E可能作为AOPP病情和预后评估的参考指标。Objective：To investigate the relationship between the blood oxygen saturation （SpO2）, Glasgow coma scale （GCS） and serum eholinesterase （AchE） of acute organophosphate poisoning （AOPP） with the illness severity and prognosis. Methods：76 patients with AOPP admitted in the EICU within 24 h from Jun 2012 to Jun 2015 were selected as the research objects. Half of a month case fatality rate of the cases were statistically analyzed, and SpO2, GCS score,serum level of Ache and APACHEⅡ scores of the survival and death cases were compared. The relationship between SpO2, GCS score and serum AchE level of patients with AOPP with the half of a month case fatality rate. Results：Compared with before treatment,after treatment SpO2,GCS score and serum AchE level significantly increased,while APACHEⅡ scores significantly reduced after treatment,both P〈0.05. Half of a month mortality of the 76 cases was 6.6%. SpO2, GCS score and serum AchE level in the death cases were significantly lower than those in the survival cases, while APACHEⅡ scores in the death cases were significantly higher than that in the survival cases （P〈O.05）. SpO2,GCS score and serum Ache level of the cases and APACHEII scores were negatively correlated（r=-0.858,-0.842,-0.835,P〈0.05）, while APACHEⅡ scores were positively correlated （r=0.826, P〈 0.05 ）. SpO2, GCS score and serum Ache level of the cases were negatively correlated with and its half of a month case fatality rate （r=-0.879, -0.891,-0.852, P〈0.05）. Conclusions： SpO2,GCS score and serum AchE level in patients with AOPP are low, while APACHEⅡ scores and half of a month case fatality rate are high, the extent of coma, degree of hypoxia and the illness severity is severe and prognosis is poor. SpO2, GCS score and serum Ache level are related to illness severity and prognosis and they may as reference index of evaluation of illness severity and prognosis in patients with AOPP.

关 键 词：SPO2 GCS评分 乙酰胆碱酯酶 急性有机磷中毒 病情 预后 关系 

分 类 号：R595.4[医药卫生—内科学]