化疗联合微移植诱导治疗难治及复发急性髓系白血病疗效观察  

Efficacy of micro transplantation induction combined with chemotherapy for refractory and relapsed acute myeloid leukemia

作　　者：王颖[1] 陈任安[1] 李国辉[1] 尹郸丹[1] 赵辉[1] 及月茹[1] 亓晖[1] 陈怡[1] 付伟[1] 刘利[1] 

机构地区：[1]第四军医大学唐都医院血液内科,西安710038

出　　处：《第三军医大学学报》2016年第12期1347-1349,共3页Journal of Third Military Medical University

摘　　要：目的研究化疗联合微移植方案治疗难治及复发急性髓系白血病(acute myeloid leukemia,AML)的疗效。方法收集2014年2-8月在唐都医院血液内科采用化疗联合微移植方案诱导治疗的12例难治及复发急性髓系白血病患者,对治疗效果进行分析。结果 12例患者均完成1个疗程的化疗联合微移植,其中获得完全缓解3例,部分缓解3例,未缓解6例,有效率50%。达到完全缓解的3例中2例随后分别行二次微移植、异基因骨髓移植治疗,1例患者在第1次微移植后1个月时出现移植物抗宿主病(GVHD)导致死亡。部分缓解3例中2例行二次微移植治疗,仍未缓解,1例放弃治疗。6例未缓解中2例分别行二次微移植、异基因骨髓移植结果均未缓解,2例因并发症于院外死亡,2例放弃治疗。结论化疗联合微移植提高了难治、复发ANLL的缓解率,并且降低单纯化疗的毒性作用,是难治复发ANLL的较好的治疗手段。Objective To determine the efficacy of micro transplantation induction combined with chemotherapy for refractory and relapsed acute myeloid leukemia（ AML）. Methods Totally 12 refractory and relapsed AML patients who were treated with chemotherapy and micro transplantation in our department from February to August 2014 were enrolled in this study,and their outcomes were analyzed. Results All the patients had finished 1 course of treatment,and among them,3 patients achieved complete remission（ CR）,3 partial remission（ PR）,while the other 6 patients non-remission（ NR） to our treatment. Two CR patients then received a second micro transplantation and allogeneic bone marrow transplantation（ allo-BMT）,and the other 1 died of GVHD in 1 month after first micro transplantation. The 2 PR patients also experienced a second micro transplantation,but both had no effect,and the other gave up the treatment at last. Of the 6NR patients,1 patient received a second course of micro transplantation and 1 patient received allo-BMT,but the results remained the same,still NR. The other 2 patients died of complications,and the left 2 patients gave up the treatment. Conclusion Micro transplantation and chemotherapy elevates the remission rate in the treatment of refractory and relapsed AML and reduces the toxicity of chemotherapy,and is a good treatment for AML.

关 键 词：急性髓系白血病 难治 复发 微移植 

分 类 号：R617[医药卫生—外科学] R730.53[医药卫生—临床医学]