同位素标记胞嘧啶的合成研究  

Synthesis of Isotope Labeled Cytosine

作　　者：徐建飞[1] 杜晓宁[1] 王伟[1] 雷雯[1] 侯捷[1] 

机构地区：[1]上海化工研究院同位素所,上海200062

出　　处：《化学试剂》2016年第6期572-574,578,共4页Chemical Reagents

基　　金：上海化学试剂产业技术创新战略联盟能力提升建设项目(14DZ0511800)

摘　　要：设计了以正丁醇为溶剂,氰基乙醛缩二乙醇和同位素标记尿素混合回流反应,再在酸作用下进行环化反应制备得到标题化合物。设计的合成路线操作简单、工艺流程短、副产物少,收率可达80%,同位素丰度没有降低。产物经HPLC、IR、MS、1HNMR和13CNMR表征。结果表明,化学纯度>99%,同位素丰度>98 atom%。A novel synthesis method of isotope labeled cytosine was designed.Butanol as solvent,3,3-diethoxypropionitrile and isotope labeled urea mixed reflux reaction,then cyclization react to prepare for isotope labeled cytosine under acid.Synthesis route had the advantages of simple operation,short process,less side product,the yield was more than 80%,labeled isotope abundance is not diluted.The product was confirmed by HPLC,IR,MS,^1HNMR and^13 CNMR.The chemical purity was more than 99%,isotope enrichment was more than 98 atom%.

关 键 词：同位素 胞嘧啶 合成 

分 类 号：O621.3[理学—有机化学] R817[理学—化学]