基于“组分结构”理论对丹皮、赤芍和白芍化学成分的对比研究  

Comparison of chemical compositions in Moutan Cortex,Paeoniae Rubra Radix and Paeoniae Alba Radix based on "component structure" theory

作　　者：章丽[1,2] 赵冰洁[2] 袁嘉瑞 汪春飞 封亮[2] 贾晓斌[2] 

机构地区：[1]江苏大学药学院,江苏镇江212013 [2]江苏省中医药研究院国家中医药管理局中药口服释药系统重点研究室,江苏南京210028

出　　处：《中国中药杂志》2016年第10期1835-1842,共8页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81202906;81130070);江苏省自然科学基金项目(BK2012491);中央本级重大增减支项目(2060302)

摘　　要：基于"组分结构"理论对丹皮、赤芍与白芍化学成分进行分析比较。采用HPLC-DAD技术,分析了13批丹皮,14批不同产地的赤芍与10批不同产地的白芍药材,并运用聚类分析,主成分分析等分析方法进行分析;利用F检验考察了丹皮、赤芍与白芍主成分间的显著性差异程度。建立了13批丹皮、14批赤芍与10批白芍药材的高效液相色谱指纹图谱,指认了7个萜苷类和酚酸类成分,根据系统聚类分析、主成分分析的结果,并结合"组分结构"理论对丹皮、赤芍与白芍进行对比研究。丹皮、赤芍与白芍功效不同,通过试验比较研究丹皮、赤芍与白芍中的主要化学成分的质量分数及其配比,发现存在显著性差异。To analyze and compare the chemical compositions of Moutan Cortex,Paeoniae Rubra Radix and Paeoniae Alba Radix based on ＂ component structure＂ theory. Thirteen batches of Moutan Cortex,14 batches of Paeoniae Rubra Radix from different origins and 10 batches of Paeoniae Alba Radix from different origins were analyzed by HPLC-DAD method. Hierarchical cluster analysis and principal component analysis were used for analysis. The significant differences of principal component from Moutan Cortex,Paeoniae Rubra Radix and Paeoniae Alba Radix were investigated by using F test. HPLC fingerprints were established for 13 batches of Moutan Cortex,14 batches of Paeoniae Rubra Radix and 10 batches of Paeoniae Alba Radix,and 7 glycosides and phenolic acids components were identified.Comparative study of Moutan Coetex,Paeoniae Rubra Radix and Paeoniae Alba Radix was conducted according to the results of hierarchical cluster analysis,principal component analysis and ＂ component structure＂ theory. Moutan Cortex,Paeoniae Rubra Radix and Paeoniae Alba Radix have significant differences in mass fraction of major chemical components and their ratios,leading to different curative effects.

关 键 词：丹皮 赤芍 白芍 指纹图谱 主成分分析 组分结构 

分 类 号：R284[医药卫生—中药学]