口服中药多糖调节肿瘤免疫应答研究思路  

Research thoughts on tumor immune responses by polysaccharide of Chinese medicine via oral administration

作　　者：王程成[1,2] 崔莉[2] 张振海[2] 封亮[2] 刘丹[2] 贾晓斌[2] 谭晓斌[3,2] 

机构地区：[1]南京中医药大学,江苏南京210046 [2]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028 [3]南京中医药大学第三临床医学院,江苏南京210028

出　　处：《中国中药杂志》2016年第10期1965-1971,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81573620;81403121);2014年江苏政府留学奖学金项目

摘　　要：肿瘤免疫疗法是当前最重大的科学进展之一,从"阴阳平衡"的角度来治疗疾病的中医理论与恢复机体免疫功能的肿瘤免疫疗法异曲同工。研究表明应用"阴阳平衡"的思路指导中药多糖免疫抗肿瘤可以更好的为肿瘤治疗服务,但是目前中药多糖抗肿瘤免疫应答的研究主要集中在提高机体的免疫功能,缺少对免疫抑制因素的探索。同时,中药多糖在组成、结构方面的分析检测复杂性加大了研究其口服吸收代谢以及体内作用机制的难度。因此该文在对中药多糖的构效关系、吸收代谢过程、肿瘤免疫分子机制等诸多方面的研究进行总结的基础上提出中药多糖调节肿瘤免疫应答的发展思路,为更好的开发肿瘤免疫治疗的新型口服中药多糖药物奠定基础。Tumor immunotherapy is one of the most significant scientific progresses. The idea of applying the traditional Chinese theory of ＂ the balance of Yin and Yang＂ to treat cancer is in accordance with that of modern tumor immune strategy. Researches indicated that polysaccharide of Chinese medicine through regulation in immune responses could offer better paradigm for tumor immune treatment under the traditional Chinese theory. However,current studies related to tumor immunotherapy largely focus on the immunity enhancement while lack of the exploration of suppressive factors. Meanwhile,the complex analysis and detection on composition as well as structure definitely increase the difficulty in mechanism of oral absorption and function in vivo. To better exploit novel Chinese medicine of polysaccharide for tumor immune treatment,this article will provide some constructive thoughts on regulation of tumor immune responses based on up to date researches of structure-function relationship,absorbent process and molecular mechanisms responsible for tumor immune as well.

关 键 词：中药多糖 构效关系 口服吸收 肿瘤免疫 阴阳平衡 

分 类 号：R285.5[医药卫生—中药学]