昆明柏化学成分研究  

Chemical Constituents of Sabina gaussenii

作　　者：杨孟妮 夏厚林[1] 胡攀[1] 文冰杰 李瑞煜[1] 张慧[1] 

机构地区：[1]成都中医药大学,中药材标准化教育部重点实验室,成都611137

出　　处：《中国实验方剂学杂志》2016年第11期68-71,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家基础科学人才培养项目(2014-2014);成都中医药大学中药基础基地科研训练及科研能力提高项目

摘　　要：目的：研究昆明柏Sabina gaussenii枝叶中的化学成分。方法：应用硅胶,羟丙基葡聚糖凝胶（Sephadex LH-20）,RP-18,MCI-gel柱色谱和半制备HPLC等手段进行分离纯化;根据理化性质和波谱学方法鉴定化合物的结构。结果：从昆明柏枝叶乙醇提取物的乙酸乙酯萃取部位中分离得到7个化合物,分别鉴定为（7S,8R）-dihydro-3-hydroxy-8-hydroxy-methyl-7-（4-hydroxy-3-methoxyphenyl）-1-benzofuranpropanol（1）,（8R,8＇S,7S）-4＇-（3″-methoxyrhamnopyranosyl）oxy-8＇-hydroxy-3,3＇,4-trimethoxy-8-hydroxymethyl-lign-7-9＇-lactone（2）,7S,8R-erythro-4,7,9,9＇-tetrahydroxy-3,3＇-dimethoxy-8-O-4＇-neolignan（3）,7S,8Sthreo-4,7,9,9＇-tetrahydroxy-3,3＇-dimethoxy-8-O-4＇-neolignan（4）,leucoseceptoside A（5）,焦地黄苯乙醇苷D（6）,blumenol A（7）。结论：化合物1-7均为首次从该植物中分离得到。Objective： To study the chemical constituents from the branches and leaves of Sabina gaussenii. Method： Silica gel, Sephadex LH-20, RP-18, MCI-gel column chromatography, semi-preparative HPLC and other means were used to isolate an purify the constituents, the structures of the compounds were identified by physicochemical properties and spectral data. Result： Seven compounds were obtained from the ethyl acetate fraction of ethanol extract in the branches and leaves of S. gaussenii and identified as（ 7S,8R）-dihydro-3-hydroxy-8-hydroxy-methyl-7-（ 4-hydroxy-3-methoxyphenyl）-1-benzofuranpropanol（ 1）,（ 8R,8＇ S,7S）-4＇-（ 3″-methoxyrhamnopyranosyl） oxy-8＇-hydroxy-3,3＇,4-trimethoxy-8-hydroxymethyl-lign-7-9＇-lactone（ 2）,7S,8R-erythro-4,7, 9, 9＇-tetrahydroxy-3, 3＇-dimethoxy-8-O-4＇-neolignan（ 3）, 7S, 8S-threo-4, 7, 9, 9＇-tetrahydroxy-3,3＇-dimethoxy-8-O-4＇-neolignan（ 4）,leucoseceptoside A（ 5）,coke to yellow benzene glycosides D（ 6）,and blumenol A（ 7）. Conclusion： Compounds 1-7 were all obtained from S. gaussenii for the first time.

关 键 词：柏科 昆明柏 化学成分 木脂素 

分 类 号：R284.1[医药卫生—中药学]