玉簪属甾体类成分及其药理活性研究进展  

Research Progress on Steroids From Genus Hosta and Their Pharmacological Activities

作　　者：杨丽[1] 赵晶晶[2] 方奕巍[3] 朱继孝[1] 王秀梅[1] 何军伟 钟国跃[1] 

机构地区：[1]江西中医药大学,南昌330004 [2]广东省妇幼保健院药学部,广州511400 [3]赣南医学院第一附属医院,江西赣州341000

出　　处：《中国实验方剂学杂志》2016年第11期230-234,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81503357);江西中医药大学人才引进项目(2014RC003)

摘　　要：我国玉簪属植物有4种,为汉族、蒙古族、傣族、纳西族等多个民族使用的传统草药,药用历史悠久,具有清热解毒、止咳、利咽喉之功效,被载录《中药大辞典》,《中华本草》,《中国民族药志要》,《中华本草·蒙药卷》,《内蒙古药材标准》等书籍中。以玉簪花为主的上市蒙药复方有"玉簪清咽十五味丸","玉簪清咽十五味散"和"清咽六味散"3个品种,主要用于治疗咽喉肿痛、气喘、音哑和胸肋刺痛。系统查阅中国知网,万方,维普,Web of Science,Sci Finder,Pubmed等国内外多个数据库,结果表明甾体类化合物是该属植物的主要和特征性成分,具有抗炎、抗肿瘤和抗菌的作用。但是,这些药理作用的物质基础及作用机制尚不明确。研究发现,中草药来源的甾体皂苷具有类似于糖皮质激素的抗炎作用,其作用依赖于下丘脑-垂体-肾上腺皮质轴。因此,研究玉簪属中甾体类化合物及其抗炎活性,对于阐述该属抗炎作用的物质基础及作用机制研究具有重要的意义。然而,我国分布的玉簪属4个种植物相关的化学成分与药理活性研究较少。本文对国内外玉簪属中甾体类进行化学成分与生物活性相关的内容进行了文献整理、分析及总结,以期为该属植物资源的质量控制、临床应用及合理开发提供参考。There are four species from the genus Hosta in China,and they have been used as traditional folk medicines by Han,Mongolian,Thai,Naxi and many other nationalities for a long history. With the functions of clearing away heat and toxic materials, and relieving cough and sore throat, they were collected in Great Dictionary of Chinese Medicine,Chinese Materia Medica,Zhongguo Minzuyao Zhiyao,Chinese Materia MedicaMongolian Medicine,Inner Mongolia Medicinal Standard and other books. The commercially available Mongolian medicines with flowers of Hosta plantaginea（ Lam.） Aschers as the main medicinal material include Yuzan Qingyan Shiwuwei Wan,Yuzan Qingyan Shiwuwei San,and Qingyan Liuwei San,mainly used for swollen and sore throats,asthma,hoarseness,and sternocostal tingling. Comprehensive analysis of the literature from CNKI,Wanfang,Web of Science,Sci Finder,Pubmed and other databases showed that steroidal compounds were the major and representative constituents in the plant of Hosta, displaying anti-inflammatory, anti-tumor, and antimicrobial activities. However,the medicinal effectiveness and action mechanisms for the above pharmacological actions are still unknown. The studies showed that steroidal saponins isolated from Chinese herbal medicine had anti-inflammatory effect relying on hypothalamic-pituitary-adrenal cortex axis, similar to the glucocorticoids.Therefore,study on the steroids from the genus Hosta and their anti-inflammatory activities is very import for elucidating the medicinal effectiveness and mechanism of anti-inflammatory effect of genus Hosta. However,there are few studies on the chemical constituents and pharmacological activities of genus Hosta in China. This review aims to provide reference for the quality control,clinical application and reasonable development of Hosta plants by sorting,analyzing and summarizing the researches both at home and abroad on steroids constituents from genus Hosta and their biological activities.

关 键 词：玉簪属 甾体 化学成分 药理活性 

分 类 号：R284.1[医药卫生—中药学]