医院病原菌分布及耐药性研究  

Distribution and drug resistance of pathogens in a hospital

作　　者：陈君[1] 陈松[1] 陈轼[1] 

机构地区：[1]杭州市第三人民医院检验科,浙江杭州310009

出　　处：《中国微生态学杂志》2016年第5期584-586,597,共4页Chinese Journal of Microecology

摘　　要：目的分析医院临床病原菌分布及对抗菌药物的耐药性,指导临床合理使用药物。方法采用药敏分析仪VETEK-2Compact对医院2014年1月至12月病原菌进行分离培养、鉴定和药物敏感性试验。结果病原菌分布以革兰阴性杆菌为主,占45.18%,主要有大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌等。其次为革兰阳性球菌,占40.11%,主要有金黄色葡萄球菌、溶血葡萄球菌,表皮葡萄球菌等,对万古霉素和替考拉宁几乎完全敏感。再次是真菌占14.71%,主要有白色假丝酵母菌、光滑假丝酵母菌、热带假丝酵母菌等。结论病原菌耐药性仍然是目前临床面临的最为严峻的课题之一,掌握医院内病原菌的分布及耐药性,有助于更好地指导临床合理用药。Objective To analyze the distribution and drug resistance of the clinical isolates of pathogens to guide the reasonable clinical use of antibiotics.Methods VETEK-2Compact drug susceptibility analysis system was used for the isolation,cultivation,identification and detection of drug susceptibility of the pathogens collected from Jan 2014 to Dec 2014.Results Gram-negative bacilli were the predominant pathogens,accounting for 45.18%.Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa and Acinetobacter baumannii were the major species of gram-negative bacilli.Gram-positive cocci accounted for40.11%,among which Staphylococcus aureus,Staphylococcus haemolyticus and Staphylococcus epidermidis were the predominant species,and nearly all the strains were susceptible to vancomycin and teicoplanin.The isolated fungi accounted for 14.71%,among which Candida albicans,Candida glabrata,and Candida tropicalis were dominant.Conclusion The drug resistance remains one of the most serious issues that the hospitals are facing,and the understanding of the distribution and drug resistance of pathogens may contribute to the reasonable clinical use of antibiotics.

关 键 词：病原菌 耐药性 分布 

分 类 号：R446.1[医药卫生—诊断学]