1-甲基海因的合成  

STUDY ON THE SYNTHESIS OF 1-METHYLHYDANTOIN

作　　者：韩宏伟 

机构地区：[1]山东齐鲁石化齐泰石油化工有限公司,山东淄博255068

出　　处：《精细石油化工》2016年第3期78-81,共4页Speciality Petrochemicals

摘　　要：以丙烯腈工段副产的氢氰酸为原料,经4步反应制备了1-甲基海因,总收率为75.0%。较佳工艺条件是：1）羟基乙腈的制备。以氢氧化钠为催化剂,反应温度为10～15℃,收率达98%。2）甲氨基乙腈的制备。n（甲胺）∶n（羟基乙腈）=1.1∶1,反应温度为15～20℃,收率达96.3%。3）肌氨酸的制备：n（甲氨基乙腈）∶n（氢氧化钠）=1∶1.2,反应温度90℃,收率达96%。4）1-甲基海因的制备：n（肌氨酸）∶n（氰酸钠）∶n（硫酸）=1∶1.5∶0.15,反应温度100℃,收率达83%。1-Methylhydantoin was synthesized by using hydrocyanic acid as raw material in 4-steps reactions with 75%total yield.The optimum reaction conditions of each step were obtained：1）preparation of glycolonitrile,NaOH as catalyst,reaction temperature is 10-15 ℃,the yield is 98%;2）preparation of methylaminoacetonitrile,n（CH3NH2）∶n（glycolonitrile）=1.1∶1,reaction temperature is 15-20 ℃,the yield is 96.3%;3）preparation of sarcosine,n（methylaminoacetonitrile）∶n（NaOH）=1∶1.2,reaction temperature is 90℃,the yield is 96%;4）preparation of 1-methylhydantoin,n（sarcosine）∶n（NaOCN）=1∶1.5,0.15 equiv H2SO4as catalyst,reaction temperature is 100℃,the yield is 83%.The implementation of the process expanded the application of hydrocyanic acid in the fine chemicals.

关 键 词：氢氰酸 羟基乙腈 甲氨基乙腈 肌氨酸 1-甲基海因 合成 

分 类 号：TQ463.5[化学工程—制药化工]