初诊多囊卵巢综合征患者空腹血清Pentraxin3的水平变化及意义  

Changes and significance of fasting serum Pentraxin3 levels in patients with newly-diagnosed polycystic ovarian syndrome

作　　者：张雨[1] 胡红琳[1] 王岩[1] 王长江[1] 

机构地区：[1]安徽医科大学第一附属医院内分泌科,合肥230022

出　　处：《安徽医科大学学报》2016年第6期883-887,共5页Acta Universitatis Medicinalis Anhui

基　　金：中华医学会临床医学科研专项资金项目(编号:13040420427);安徽高校省级科学研究项目(编号:KJ2013Z126)

摘　　要：目的检测初诊多囊卵巢综合征(PCOS)患者空腹血清Pentraxin3(PTX3)水平,探讨其在PCOS发生发展中的可能作用。方法选取78例PCOS患者(PCOS组)和67例健康体检者(对照组),两组按体质指数(BMI)分为体重正常(PCOS-NW,对照-NW)亚组和超重/肥胖(PCOS-OW/OB,对照-OW/OB)亚组。测量身高、体重、腰围(WC)、臀围。测定各组空腹血清PTX3水平、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)、空腹血糖(FBG)、餐后2 h血糖(P2hB G)、空腹胰岛素(FINS);计算BMI、腰臀比(WHR)、稳态模型胰岛素抵抗指数(HOMA-IR)。结果(1)PCOS组和对照组中OW/OB组PTX3水平均低于NW组(P<0.05,P<0.01);(2)Pearson相关性分析显示空腹血清PTX3水平与BMI、FBG、P2hB G、FINS、HOMA-IR呈负相关性(P<0.05);(3)多元回归分析结果显示影响PTX3水平的重要因素是FBG;(4)二分类Logistic回归分析显示PTX3是PCOS发生的保护因素。结论 PTX3可能参与了PCOS的发生,低水平的PTX3可能是PCOS发生发展中的危险因素。Objective To evalute the variation of fasting serum Pentraxin3（ PTX3） levels and its role in the development of patients with newly-diagnosed polycystic ovarian syndrome（ PCOS）. Methods 78 patients and 67 healthy subjects were selected and each group was divided into normal weight subgroup（ PCOS-NW,control-NW） and overweight / obese subgroup（ PCOS-OW / OB,control-OW / OB） according to the body mass index（ BMI）. Height,weight,waist circumstance（ WC） and hip circumference were measured. Serum PTX3 level,total cholesterol（ TC）,triglyceride（ TG）,high-density lipoprotein（ HDL）,low-density lipoprotein（ LDL）,luteinizing hormone（ LH）,follicle stimulating hormone（ FSH）,testosterone（ T）,fasting blood glucose（ FBG）,postprandial 2 h blood glucose（ P2 h BG）,fasting insulin（ FINS） were also measured. BMI,waist-hip ratio（ WHR） and homeostasis model assessment of insulin resistance（ HOMA-IR） were calculated. Results 1 Fasting serum PTX3 levels in PCOS-OW / OB and control-OW / OB were significantly lower than those in PCOS-NW and control-NW（ P 〈0. 05,P 〈0. 01）; 2Fasting serum PTX3 level was found correlated negatively with BMI,FBG,P2 h BG,FINS and HOMA-IR（ P〈 0. 05）; 3 Multiple stepwise regression analysis demonstrated that FBG was the influencing factor of serum PTX3level; 4 Binary logistic regression analysis showed that PTX3 was the protective factor of PCOS. Conclusion The serum PTX3 level may play a very important role in the development of PCOS. Lower PTX3 level may be a risk factor in the development of PCOS.

关 键 词：多囊卵巢综合征 胰岛素抵抗 Pentraxin3 

分 类 号：R711.75[医药卫生—妇产科学]