抗菌药物跨生物膜传递方式的研究进展  

Process of strategies for antimicrobial agent delivery to biofilm

作　　者：冯梦蝶[1] 曾韦锟[1,2] 

机构地区：[1]昆明理工大学医学院医学微生物学教研室,昆明650500 [2]昆明学院医学院临床检验教研室,昆明650214

出　　处：《复旦学报（医学版）》2016年第3期373-378,共6页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金(31160193);云南省教育厅科学研究基金重点项目(2015Z168)~~

摘　　要：生物膜是指单一或混合微生物附着于生物或者合成的表面具有一定组织结构的微生物聚集体,其组成成分包括微生物自身及其分泌的多糖基质、纤维蛋白及脂质蛋白。生物膜除了能够帮助细菌耐受多种环境压力,例如紫外线、噬菌体等,更为重要的是它能够阻碍抗生素进入和扩散,是病原菌耐药性形成的重要机制之一。因此,在治疗病原体感染的过程中,选择一种有效的抗菌药物是必要的,但对于形成生物膜的微生物如何将抗菌药物有效地传递至生物膜从而彻底治愈成膜病原菌感染是至关重要的,所以本文就抗菌药物传递至生物膜的运输方式进行综述。Biofilm,a certain organizational structure,is formed by the attachment of single or mixed microbial communities to a variety of biological and/or synthetic surfaces.It contains microbes themselves and the secretion of polysaccharide matrix,fiber protein,and proteolipid proteins.In addition to help the bacteria resistant to a variety of environmental stresses,such as ultraviolet rays,bacteriophages and so on,more importantly,biofilm can block antibiotics access and diffuse to bacteria,which is one of the important mechanisms of pathogen resistance formation.In the course of pathogens treatment,it is necessary to select an effective antimicrobial agent,but for the forming biofilm pathogens,it is essential to deliver antimicrobial drugs effectively to biofilm for complete cure.In this article,strategies for antimicrobial drug delivery to biofilm are reviewed.

关 键 词：抗菌药物 生物膜 药物传递方式 

分 类 号：R915[医药卫生—微生物与生化药学]