大理地区糖化血红蛋白切点的探讨  

Investigation on the Cutoff Point for Glycosylated Hemoglobin in Dali Region

作　　者：和迎春 朱星成 尹波 王冬菊 

机构地区：[1]大理大学附属医院,云南大理671000 [2]大理大学大理教学医院,云南大理671000

出　　处：《大理大学学报》2016年第4期64-66,共3页Journal of Dali University

摘　　要：目的:探讨大理地区应用糖化血红蛋白(Hb Al C)诊断2型糖尿病和空腹血糖调节受损(IFG)的可行性,并确定相应的诊断切点。方法:2型糖尿病(T2DM)患者332例、空腹血糖调节受损(IFG)175例,行葡糖糖耐量试验(OGTT)及糖化血红蛋白(Hb Al C)检测,采用ROC曲线分析以确定诊断2型糖尿病对应Hb Al C最佳切点。结果:IFG组和T2DM组的FBG、Hb Al C平均水平高于健康对照组,差异具有统计学意义(P<0.05)。Hb Al C用于诊断2型糖尿病的最佳临界值为6.25%,敏感度为86.5%,特异度95.2%,曲线下面积(AUC)为0.959(95%置信区间0.945-0.973)。结论:Hb A1c用于评估IFG的最佳临界值为5.51%,Hb A1c用于诊断2型糖尿病的最佳临界值为6.25%,Hb Al C可作为T2DM诊断标准之一。Objective： To investigate the feasibility of hemoglobin A1C（HbA1C）diagnosing type 2 diabetes mellitus and Impaired Fasting Glucose （IFG）, and determine the diagnostic cut point. Methods： Oral Glucose Tolerance Test （OGTT） and HbA1C were detected in patients with 332 cases of type 2 diabetes mellitus （T2DM） and 175 cases of Impaired Fasting Glucose. Receiver Operating Characteristic Curve（ROC）was used to determine the optimal HbA1C diagnostic cutoff point for type 2 diabetes mellitus. Results： The FBG and HbA1C levels of the IFG and T2DM group were higher than normal healthy control group with statistical significance（P〈0.05）. According to ROC, the optimal cutoff point of HbA1C for the diagnosis of type 2 diabetes mellitus was 6.25%, and its sensitivity was 86.5%, its specificity 95.2%, the AUC was 0.959（95%CI：0.945-0.973）. Conclusion：The optimal cutoff point of HbA1C for the diagnosis of Impaired Fasting Glucose was 5.51%, and the optimal cutoff point of HbA1c for the diagnosis of type 2 diabetes mellitus was 6.25%. HbA1C is an available parameter in diagnosing T2DM.

关 键 词：糖尿病 糖化血红蛋白 空腹血糖调节受损 

分 类 号：R587.1[医药卫生—内分泌]