人巨细胞病毒感染及免疫机制研究进展  

Research Progress of Human Cytomegalovirus Infection and Immune Mechanism

作　　者：郑丽丽[1] 杨亚培[1,2] 

机构地区：[1]聊城市人民医院中心实验室,山东聊城252000 [2]山东大学附属省立医院心内科,济南250021

出　　处：《医学综述》2016年第11期2114-2117,共4页Medical Recapitulate

基　　金：山东省博士后创新项目专项资金(201303024)

摘　　要：巨细胞病毒(CMV)感染分先天性感染和移植后感染,尤其对接受异体移植和免疫缺陷的患者致病性更强。其诱导的免疫致病机制十分复杂,目前尚无有效预防措施,因此明确其感染机制及机体对CMV感染的免疫应答反应,对于预防和治疗CMV感染至关重要。目前,关于CMV感染免疫机制的研究主要集中于T细胞、自然杀伤细胞(NK细胞)、NK细胞受体及相关抑制性基因表达等方面,其部分致病机制还存在争议。Cytomegalovirus（ CMV） infection includes congenital and post-transplant infection. CMV causes signi cant morbidity in the immunodeficiency patients and transplant recipients. But the immune pathogenesis of CMV infection is very complex,and there is still no effective preventive measures,therefore,we should clarify the infection mechanism and the body＇s response to CMV infection,which is very important and helpful for the prevention and treatment of CMV infection. At present,studies on CMV infection immune mechanism are mainly concentrated on T cells,natural killer（ NK） cells and NK cell receptor and the related suppresser gene expression,and some of the pathogenic mechanisms are still controversial.

关 键 词：巨细胞病毒 移植后感染 免疫机制 

分 类 号：R373.9[医药卫生—病原生物学]