妊娠高血压疾病妇女D-二聚体及凝血指标检测的临床意义  

The Clinical Significance of D-dimer and Coagulation Test for Patients with Gestational Hypertension

作　　者：叶智良[1] 邝绍钧[1] 杨晓明[1] 赵新[1] 陈珮琦 

机构地区：[1]佛山市妇幼保健院检验科,广东佛山528000

出　　处：《医学综述》2016年第11期2215-2217,共3页Medical Recapitulate

摘　　要：目的分析妊娠高血压疾病妇女D-二聚体及凝血指标检测的临床意义。方法选取2012年1月至2015年12月佛山市妇幼保健院诊治妊娠晚期合并妊娠高血压综合征25例(A组)、正常妊娠晚期孕妇25例(B组)以及同时期体检非妊娠健康妇女25例(C组)共同进行D-二聚体及凝血指标检测,包括凝血酶原时间、活化部分凝血活酶时间、凝血酶时间和纤维蛋白原。结果 A组D-二聚体、纤维蛋白原水平显著高于B组和C组[(0.76±0.05)mg/L比(0.40±0.07)mg/L;(0.14±0.04)mg/L;(5.79±0.42)g/L比(4.18±0.46)g/L、(3.43±0.38)g/L],B组显著高于C组,差异有统计学意义(P<0.05);A组凝血酶原时间与活化部分凝血活酶时间显著短于B组和C组[(10.15±0.32)s比(12.42±0.56)s,(13.12±0.55)s;(26.42±3.12)s比(31.04±3.24)s,(34.68±3.48)s],B组显著低于C组,差异有统计学意义(P<0.05)。结论妊娠妇女与妊娠合并高血压妇女的凝血指标均较高,在妊娠前对孕妇进行D-二聚体及凝血指标检测有助于减少妊娠并发症,提高孕妇的安全,可以加入产妇分娩前的检测项目。Objective To analyze the clinical significance of D-dimer and coagulation testing for patients with gestational hypertension. Methods Total of 25 cases of gestational hypertension in late term（ group A）,25 cases of normal pregnant women in late term（ group B） and 25 cases of non-pregnant healthy women（ group C） in Foshan Maternal and Child Health Hospital from Jan. 2012 to Dec. 2015 were included in the study,D-dimer and coagulation testing,including thrombotic time,activated partial thermoplastic time,thrombin time and fibrinogen were tested for all cases. Results D-dimer,fibrinogen levels of group A were higher than group B and group C[（ 0. 76 ± 0. 05） mg / L vs（ 0. 40 ± 0. 07） mg / L,（ 0. 14 ± 0. 04） mg / L;（ 5. 79 ± 0. 42） g/L vs（ 4. 18 ± 0. 46） g/L,（ 3. 43 ± 0. 38） g/L],and group B were higher than group C,the differences were statistically significant（ P〈0. 05）. Prothrombin time and activated partial thromboplastin time of group A were less than group B and group C[（ 10. 15 ± 0. 32） s vs（ 12. 42 ± 0. 56） s,（ 13. 12 ±0. 55） s;（ 26. 42 ± 3. 12） s vs（ 31. 04 ± 3. 24） s,（ 34. 68 ± 3. 48） s],and group B were less than group C,the differences were statistically significant（ P〈0. 05）. Conclusion The coagulation index of pregnant women and patients with gestational hypertension were higher,D-dimer and coagulation tests before pregnancy can help to reduce pregnancy complications,improve the safety of the pregnant women,and can be added into prenatal test items.

关 键 词：妊娠晚期合并妊娠高血压综合征 D-二聚体 凝血指标检测 

分 类 号：R714[医药卫生—妇产科学]