中医综合干预方案对卒中后轻度认知功能障碍疗效评价  

Evaluation of TCM comprehensive intervention on mild post-stroke cognitive impairment

作　　者：金香兰[1] 李涛[2] 贾蓓[2] 姬少珍 刘玥[2] 陈宝鑫[2] 侯小兵[3] 牛焕敏 黎明全[5] 张虎 曹晓岚[7] 杨健[8] 田军彪[9] 张宪忠[10] 李书珍[2] 张允岭[1] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]北京中医药大学,北京100029 [3]中国中医科学院望京医院,北京100102 [4]北京市第一中西医结合医院.北京100026 [5]长春中医药大学附属医院,长春130021 [6]北京市顺义区中医院,北京101300 [7]山东中医药大学附属医院,济南250011 [8]重庆市中医院,重庆400011 [9]河北医科大学中医院,石家庄050011 [10]山东省日照市中医医院,日照276800

出　　处：《中华中医药杂志》2016年第6期2129-2132,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：2010年中医药行业科研专项资助(No.201007002);2013年首都临床特色应用研究(No.Z13110700 2213151)~~

摘　　要：目的:综合评价中医综合干预方案对卒中后轻度认知功能障碍患者的临床疗效。方法:纳入卒中后轻度认知功能障碍患者,随机分为治疗组、对照组,治疗组给予中药(复方苁蓉益智胶囊)+中医特色疗法+非药物干预,对照组给予非药物干预,疗程180d。采用蒙特利尔认知评估量表(MoCA)、日常生活活动能力量表(ADL)及中医核心症状对干预方案进行综合评价。结果:干预180d后,治疗组较对照组MoCA总分显著提高明显(P<0.01);两组ADL总分均较干预前下降(P<0.01,P<0.05);治疗组对"言谈不知首尾,时作时止""转盼遗忘""语后便忘,思量不能""神思不聚""言语懒""兴趣索然""烦躁易怒"等7条中医核心症状有显著改善作用(P<0.01,P<0.05)。结论:中医综合干预方案能够改善卒中后轻度认知功能障碍患者认知功能,提高日常生活能力,改善中医核心症状,具有较好的临床疗效。Objective： To evaluate the efficacy of TCM comprehensive intervention on the mild post-stroke cognitive impairment. Methods： The cases of patients with mild post-stroke cognitive impairment were randomly divided into intervention group and control group. The intervention group was treated with traditional Chinese medicine（compound Congrong Yizhi Capsule） ＋ TCM featured therapies ＋ non-medicinal intervention, and the control group was treated with non-medicinal intervention, with a 180-day treatment course. The score of Montreal cognitive assessment（MoCA）, activities of daily living（ADL） and the core terminology of TCM were used to evaluate the effect of the intervention. Results： The totle score of MoCA in the intervention group was higher than that in the control group（P〈0.01）. Compared with before the treatment, the totle score of ADL in the two groups after the treatment were improved, with a statistical difference（P〈0.01, P〈0.05）. It also showed that 7 pieces of core symptoms in the intervention group were improved, such as occasional forgetfulness when talk, forgetfulness in the twinkling of an eye, forgetfulness after talk that don＇t memory by thinking, distraction, less communication, loss of interest, and irritability（P〈0.01, P〈0.05）. Conclusion： The TCM comprehensive intervention could improve the mild post-stroke cognitive impairment from the cognitive functions, activities of daily living and the TCM core symptoms. Therefore, it has a good clinical efficacy.

关 键 词：中医综合干预 卒中 轻度认知障碍 疗效 

分 类 号：R277.7[医药卫生—中医学]