除草剂Tembotrione的合成研究  

Synthesis of Herbicide Tembotrione

作　　者：左静[1] 张大永[1] 

机构地区：[1]中国药科大学药物科学研究院,南京210009

出　　处：《现代农药》2016年第3期20-22,28,共4页MODERN AGROCHEMICALS

摘　　要：Tembotrione为HPPD抑制剂类除草剂,具有三酮结构。以3-氯-2-甲基苯胺为起始原料,经由重氮化、傅克酰基化、氧化、卤仿、酯化、溴代、缩合、水解、酰氯化以及缩合、重排反应合成目标化合物tembotrione。该工艺总收率达到60%,目标产物质量分数在95%以上。工艺条件温和,原料易得,适合工业化大生产。Tembotrione is an important product in HPPD herbicides.The synthetic methods of tembotrione used3-chloro-2-methylaniline as the starting material.The target product was prepared via diazotization,Friedel-Crafts acylation,oxidization,haloform reaction,esterification,bromination,condensation,hydrolysis,chloridization,rearrangement reaction,etc.The total yield was more than 60%,the purity of tembotrione was over 95%.

关 键 词：tembotrione HPPD类除草剂 合成方法 3-氯-2-甲基苯胺 

分 类 号：TQ457[化学工程—农药化工]