黏液脓性宫颈炎患者病原体感染的调查分析  

Survey of pathogen infections in mucopurulent cervicitis

作　　者：朱善芳[1] 周秀芬[1] 夏晓平[1] 李睿[1] 潘娜娜[1] 

机构地区：[1]安徽医科大学附属六安医院妇科,安徽六安237005

出　　处：《中华医院感染学杂志》2016年第11期2571-2573,共3页Chinese Journal of Nosocomiology

基　　金：安徽省重点科技研究计划基金资助项目(20130127)

摘　　要：目的分析黏液脓性宫颈炎患者的感染因素及病原体分布,为患者的抗菌药物治疗提供依据。方法将2011年3月-2014年12月医院妇科就诊的580例黏液脓性宫颈炎患者及同期健康体检580名女性作为研究对象,取其宫颈分泌物并对标本进行病原体培养,分析黏液脓性宫颈炎患者病原体感染特征,对可疑单个克隆进行培养,检测黏液脓性宫颈炎患者的细菌种类并进行药敏试验。结果黏液脓性宫颈炎组患者的细菌、支原体属阳性检出率分别为67.93%、40.21%,与健康对照组比较显著高于,差异有统计学意义(P<0.05);394例细菌检测为阳性的患者共检出病原菌427株,其中革兰阳性菌267株占62.53%,革兰阴性菌160株占37.47%;大肠埃希菌、淋病奈瑟球菌均对亚胺培南无耐药性,淋病奈瑟球菌对青霉素的耐药率较高为60.46%;粪肠球菌、无乳链球菌对四环素的耐药率分别为71.64%、94.55%,无乳链球菌对克林霉素的耐药性为87.27%。结论黏液脓性宫颈炎患者存在各种病原体感染,根据宫颈分泌物样本的药敏试验结果选择抗菌药物,可以提高对黏液脓性宫颈炎的治疗效果。OBJECTIVE To analyze the risk factors and common pathogens of infections in mucopurulent cervicitis（MPC）patients,so as to provide the basis for the antimicrobial treatment of patients.METHODS A total of 580 MPC patients treated in department of gynecology and 580 healthy women were selected for the study from Mar.2011 to Dec.2014.The vaginal secretion specimens were obtained for pathogen culture,the infection characteristics of MPC pathogen were analyzed,the suspicious single clones were selected and cultured,and Phoenix microorganisms automatic identification instrument was used to identify pathogen species and drug sensitive test results.RESULTS The rate of positive bacteria and mycoplasma in MPC group were 67.93% and 40.21%,and were significantly higher than the control group（4.83% and 17.59%）（P〈0.05）.There were 394 MPC patients with bacterial infections,and 427 strains of pathogens were detected,including 267gram-positive bacteria cases,accounting for 62.53%,and 160gram-negative bacteria cases,accounting for 37.47%.Drug sensitive test showed that Escherichia coli and Neisseria gonorrhoeae were susceptibility to gentamicin and imipenem,and the drug resistance rate of N.gonorrhoeae to penicillin was 60.46%.The drug resistance rate of Enterococcus faecalis and Streptococcus agalactiae to tetracycline were 71.64%and 94.55%.The drug resistance rate of S.agalactiae to clindamycin was 87.27%.CONCLUSION MPC patients are correlated with various pathogen infections,and corresponding antibiotics should be applied according to bacterial culture and drug sensitive test results of vaginal secretion,to improve the treatment efficacy of MPC.

关 键 词：黏液脓性宫颈炎 病原体 感染 药敏试验 

分 类 号：R711.3[医药卫生—妇产科学]