偶发与复发自然流产胚胎细胞遗传学异常的关系  

Relationships of Sporadic and Recurrent Spontaneous Abortion to Cytogenetic Abnormalities

作　　者：吴菁[1] 郭莉[1] 尹爱华[1] 陈汉彪[1] 麦明琴[1] 何薇[1] 钟燕芳[1] 

机构地区：[1]广东省妇幼保健院医学遗传中心,广州511442

出　　处：《南昌大学学报（医学版）》2016年第2期39-41,48,共4页Journal of Nanchang University：Medical Sciences

基　　金：广东省医学科研基金(B2010031)

摘　　要：目的探讨偶发与复发自然流产的流产物细胞遗传学异常发生率相关性。方法选取178例发生早期自然流产孕妇,年龄(28.0±3.2)岁,按流产发生的次数分为偶发自然流产组(90例,偶发组)和复发自然流产组(88例,复发组)。孕妇在行清宫手术时取流产物绒毛组织,用原位培养方法培养并制备绒毛细胞染色体进行核型分析。结果偶发组3例培养失败,87例培养成功,异常核型39例(45%,39/87)中数目异常占92%(36/39);复发组2例培养失败,86例培养成功,异常核型48例(56%,48/86)中数目异常占90%(43/48)。2组流产物绒毛染色体核型异常率和异常类型比较差异无统计学意义(P>0.05)。结论早期胚胎染色体数目异常是导致早期流产的主要原因,与流产发生的次数无明显关系,母亲的年龄不是造成流产的最主要因素。导致多次妊娠均发生胚胎染色体异常的原因还待进一步研究。Objective To investigate the relationships of sporadic and recurrent spontaneous abortion to cytogenetic abnormalities.Methods According to the number of abortion,178 pregnant women with early spontaneous abortion（（28.0±3.2）years of age）were divided into sporadic spontaneous abortion group（n=90,sporadic group）and recurrent spontaneous abortion group（n=88,recurrent group）.The chorionic villi were obtained in uterine curettage and were cultured in situ for karyotyping.Results In sporadic group,chorionic villus culture was successful in 87 cases and unsuccessful in 3cases.Among the 87 cases,39（45%）had chromosome numerical abnormalities,and 92% of them（36/39）had numerical abnormalities.In recurrent group,chorionic villus culture was successful in 86 cases and unsuccessful in 2cases.Among the 86 cases,48（56%）had chromosome numerical abnormalities,and 90% of them（43/48）had numerical numerical abnormalities.There were no significant differences in the rates of abnormal karyotype and type between the two groups（P〉0.05）.Conclusion Chromosomal numerical numerical abnormalities,but not maternal age,are the primary cause of early spontaneous abortion.However,chromosome numerical abnormalities are not correlated with the number of abortion.The causes of recurrent embryonic chromosome numerical abnormalities need to be further studied.

关 键 词：早期自然流产 绒毛细胞 核型分析 偶发性 复发性 

分 类 号：R714.21[医药卫生—妇产科学]