急性冠脉综合征PCI术后非靶病变进展与miRNA及hs-CRP的关系  

The relationship among miRNA & hs- CRP and non- target- lesion in patients with acute coronary syndromes( ACS) after percutaneous coronary intervention( PCI) procedure

作　　者：杨莉莉[1] 赵宇[1] 王丽[1] 闫晓丹[1] 邸雅琴 汤柏赞[1] 邵海峰[1] 

机构地区：[1]齐齐哈尔医学院附属第三院心内科,161000 [2]大庆市第五医院,黑龙江165000

出　　处：《齐齐哈尔医学院学报》2016年第9期1121-1123,共3页Journal of Qiqihar Medical University

基　　金：齐齐哈尔市科学技术计划研究项目资助(项目编号SFGG-201419)

摘　　要：目的探究miRNA及hs-CRP对急性冠脉综合征PCI术后非靶病变进展的影响。方法测定217例急性冠脉综合征患者入院时及随访时的血浆miRNA-142-5p和hs-CRP浓度。所有患者经皮冠状动脉支架植入术,并于12个月后行冠状动脉造影随访。结果非靶病变进展组患者高敏CRP浓度高于非进展组患者[1.65±0.18mg/L vs 1.52±0.37mg/L,P<0.001]。进展组患者miRNA-142-5p表达水平低于非进展组患者[27.12±2.11 vs 34.73±2.67,P<0.001]。多因素回归分析显示入院时血浆hs-CRP和miRNA-142-5p高表达是非靶血管病变进展的预测因子(OR=1.207,95%CI 1.073-1.357,P=0.002和OR=0.312,95%CI 0.152-1.617,P=0.002)。结论血浆hs-CRP和miRNA-142-5p表达水平可预测急性冠脉综合征患者支架植入术后非靶血管病变的进展。Objective The aim of this study was to investigate the influence of miRNA and hs- CRP on non- targeted- lesion in patients with acute coronary syndromes（ ACS） after percutaneous coronary intervention（ PCI） procedure. Methods The serum samples were collected from 217 ACS patients to detect the level of miRNA- 14- 5p and hs- CRP during admission and follow- up periods. All patients underwent PCI with stent implantation and coronary angiograp Hy at the time of 12- months follow- up. Results The expression level of hs- CRP in progress group was significantly higher than the non- progress group [1. 65 ± 0. 18 mg / L vs 1. 52 ± 0.37 mg / L,P 0. 001]. for non- targeted vessels patients. The expression level of miRNA- 142- 5p in progress group was higher than the non- progress group as well [27. 12 ± 2. 11 vs 34. 73 ± 2. 67,P 0. 001]. Multi-factor regression analysis indicated that high expression levels of hs- CR and miRNA- 142- 5p during admission is the predictor of advance of non- targeted- lesion patients（ OR = 1. 207,95% CI 1. 073- 1. 357,P = 0. 002 and OR = 0. 312,95% CI 0. 152- 1. 617,P = 0. 002）. Conclusions The serum level of hs- CRP and miRNA- 142- 5p can predict non- targeted- lesion in patients with ACS after PCI.

关 键 词：C-反应蛋白 MIRNA 急性冠脉综合征 经皮冠状动脉介入治疗 非靶病变 

分 类 号：R541.4[医药卫生—心血管疾病]