柏艾胶囊对麻醉犬血流动力学的影响  

Bo-Ai Capsule's Hemodynamic Effects on the Anesthesia dog

作　　者：赵荣华[1] 崔晓兰[1] 

机构地区：[1]中国中医科学院中药研究所,北京100070

出　　处：《世界中医药》2016年第4期679-681,共3页World Chinese Medicine

摘　　要：目的：评价柏艾胶囊对麻醉犬血流动力学的影响。方法：本实验采用心导管介入手段观察柏艾胶囊对麻醉犬血流动力学的影响,柏艾胶囊设置2.24 g/（kg·d）、1.12 g/（kg·d）、0.56 g/（kg·d）3个剂量组,以卡托普利为阳性对照药,十二指肠给药,观察药物对麻醉犬血流动力学的变化。结果：柏艾胶囊大、中剂量组在给药后1~2.5 h,犬收缩压有不同程度降低,其降低幅度与模型对照组比较差异有统计学意义（P〈0.05,P〈0.01）;柏艾胶囊大剂量组给药后1~2.5 h总外周血管阻力明显降低;给药后1.5 h舒张压明显降低,其降低幅度与模型对照组比较差异有统计学意义（P〈0.05）。结论：柏艾胶囊具有明显降压作用,作用与收缩压、总外周血管阻力、舒张压显著降低有关,同时为进一步阐明柏艾胶囊降血压机制提供参考。Objective： To evaluate Bo-Ai capsule＇s hemodynamic effects on anesthesia dogs. Methods： The experiment adopted the cardiac catheterization intervention to observe the Bo-Ai capsule＇s hemodynamic effects on anesthetic dogs. The dosage of the capsule was set at 2. 24 g / kg / d,1. 12 g / kg / d,0. 56 g / kg / d,and the captopril,by duodenal administration,was set as the positive control drug. Changes of blood dynamics of anesthetic dogs was observed. Results： Compared with model group,systolic blood pressure and total peripheral vascular resistance decreased significantly in large and middle dose groups of Bo-Ai capsule after 1 to2. 5 hours（ P〈0. 05,P〈0. 01）. Compared with model group,diastolic blood pressure decreased significantly in large Bo-Ai capsule dose groups after 1. 5 hours（ P〈0. 05）. Conclusion： It is obvious that Bo-Ai capsule has antihypertensive effect on systolic blood pressure,total peripheral vascular resistance and diastolic blood pressure,which provides references for the antihypertensive mechanism of Bo-Ai capsule.

关 键 词：柏艾胶囊 动脉导管 静脉漂浮导管 血流动力学 

分 类 号：R654.2[医药卫生—外科学]