甘肃鼢鼠低氧适应后心功能的变化  

Variety of Cardiac Functions of Eospalax cansus after Hypoxia Acclimatization

作　　者：张静[1] 王倩[1] 钱令波[1] 杨静[1] 何建平[1] 

机构地区：[1]陕西师范大学生命科学学院,西安710119

出　　处：《四川动物》2016年第3期421-425,共5页Sichuan Journal of Zoology

基　　金：国家自然科学基金项目(No.30670360)

摘　　要：甘肃鼢鼠Eospalax cansus是生活在我国黄土高原地区的地下鼠,是一种缺氧耐受的模型鼠,具有多种机制来适应其特殊的生活环境。为了比较慢性间歇性低氧后与地面常氧状态下甘肃鼢鼠的心脏功能,将18只甘肃鼢鼠随机分为对照组(常氧)和实验组(慢性间歇性低氧)检测其心脏功能。结果表明,低氧适应后实验组的心率较对照组显著提高(P<0.05);平均颈动脉压力、左心室收缩压较对照组极显著升高(P<0.01);左心室内压最大上升速率和左心室内压最大下降速率与对照组差异无统计学意义。表明甘肃鼢鼠存在一定低氧适应机制,在低氧刺激下其心脏代偿功能得到发挥,从而减轻缺氧对其心脏的损伤。Eospalax cansus is a unique model of hypoxic tolerance and is a blind subterranean mole rat which lives on the loess plateau of China. This species develops multiple mechanisms to adapt the special environments. In this study,to detect the effects of intermittent hypoxic acclimatization on cardiac functions,eighteen E. cansus were randomly assigned to normoxia（ N） group and chronic intermittent hypoxia（ CIH） group. The results showed that,compared with the N group,CIH could significantly increase heart rate（ P〈0. 05）,and extreme significantly increase the average carotid artery pressure and the left ventricular systolic pressure（ P〈0. 01）,while no significant changes were observed in maximum rise rate of left ventricle pressure and maximum decline rate of left ventricle pressure,etc. These results indicated that E. cansus had adapted to hypoxic habitats（ underground burrow） and its cardiac compensations had been significantly developed,and these can therefore alleviate the hypoxic effects of cardiac functions.

关 键 词：甘肃鼢鼠 心功能 低氧适应 

分 类 号：Q463[生物学—生理学]