An overlooked effect of systemic anticholinergics:alteration on accommodation amplitude  

作　　者：Mehmet Ali Sekeroglu Emre Hekimoglu Mustafa Alpaslan Anayol Yasemin Tasci Ismail Dolen 

机构地区：[1]Department of Ophthalmology,Ulucanlar Eye Training and Research Hospital [2]Department of Ophthalmology,Etlik Zubeyde Hanim Maternity and Research Hospital [3]Department of Urogynecology,Etlik Zubeyde Hanim Maternity and Research Hospital

出　　处：《International Journal of Ophthalmology(English edition)》2016年第5期743-745,共3页国际眼科杂志（英文版）

摘　　要：AIM： To investigate the effect of oral solifenacin succinate, tolterodine-L-tartarate and oxybutinin hydrochloride（HCl） on accommodation amplitude.·METHODS： Female overactive bladder syndrome（OAB）patients who were planned to use oral anticholinergics,patients that uses solifenacin succinate 5 mg（Group I,n =25）, tolterodine-L-tartarate 4 mg（Group II, n =25）,and oxybutinin HCl 5 mg b.i.d.（Group III, n =25） and age matched healthy female subjects（Group IV, n =25） were recruited and complete ophthalmological examination and accommodation amplitude assessment were done at baseline and 4wk after initiation of treatment.·RESULTS： The mean age of 100 consecutive female subjects was 51.6 ±5.7（40-60）y and there were no statistically significant difference with regard to the mean age（P =0.107） and baseline accommodation amplitude（P =0.148） between study groups. All treatment groups showed a significant decrease in accommodation amplitude following a 4-week course of anticholinergic treatment（P =0.008 in Group I, P =0.002 in Group II, P =0.001 in Group III）, but there was no statistically significant difference in Group IV（P =0.065）.·CONCLUSION： A 4-week course of oral anticholinergic treatment have statistically significant effect on accommodation amplitude. Clinicians should avoid both overestimating this result, as this would unnecessarily restrict therapeutic possibilities, and also underestimating it which may lead to drug intolerance.AIM： To investigate the effect of oral solifenacin succinate, tolterodine-L-tartarate and oxybutinin hydrochloride（HCl） on accommodation amplitude.·METHODS： Female overactive bladder syndrome（OAB）patients who were planned to use oral anticholinergics,patients that uses solifenacin succinate 5 mg（Group I,n =25）, tolterodine-L-tartarate 4 mg（Group II, n =25）,and oxybutinin HCl 5 mg b.i.d.（Group III, n =25） and age matched healthy female subjects（Group IV, n =25） were recruited and complete ophthalmological examination and accommodation amplitude assessment were done at baseline and 4wk after initiation of treatment.·RESULTS： The mean age of 100 consecutive female subjects was 51.6 ±5.7（40-60）y and there were no statistically significant difference with regard to the mean age（P =0.107） and baseline accommodation amplitude（P =0.148） between study groups. All treatment groups showed a significant decrease in accommodation amplitude following a 4-week course of anticholinergic treatment（P =0.008 in Group I, P =0.002 in Group II, P =0.001 in Group III）, but there was no statistically significant difference in Group IV（P =0.065）.·CONCLUSION： A 4-week course of oral anticholinergic treatment have statistically significant effect on accommodation amplitude. Clinicians should avoid both overestimating this result, as this would unnecessarily restrict therapeutic possibilities, and also underestimating it which may lead to drug intolerance.

关 键 词：ACCOMMODATION ANTICHOLINERGICS overactive bladder 

分 类 号：R969[医药卫生—药理学]