丙泊酚对麻醉诱导期芬太尼所致咳嗽的影响  

Effects of propofol on fentanyl-induced cough during induced anesthesia

作　　者：邵庆祝 苏东安[2] 成干生 梁建英[2] 王仁美[2] 余海鹰[2] 

机构地区：[1]武警江苏总队南京分院麻醉科,210029 [2]解放军第102医院麻醉科,常州210003

出　　处：《武警医学》2016年第5期490-492,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的观察丙泊酚对麻醉诱导期芬太尼所致咳嗽的影响。方法拟行全身麻醉患者113例,年龄25~60岁,ASAⅠ或Ⅱ级,随机分为两组：对照组依次输注生理盐水0.05 ml/kg和4μg/kg芬太尼,丙泊酚组依次输入丙泊酚0.5 mg/kg和4μg/kg芬太尼。观察并记录两组患者注射芬太尼0、5、10 s时的咳嗽情况。结果对照组芬太尼引起咳嗽29例,丙泊酚组10例,两组在发生率和严重程度上均有显著的统计学意义（P〈0.0001）。本研究还显示丙泊酚能降低吸烟者的咳嗽发生率。结论芬太尼全身麻醉诱导前1 min给予0.5 mg/kg丙泊酚可有效抑制芬太尼所导致的咳嗽。Objective To study the effects of propofol on fentanyl-induced cough during anesthesia induction. Methods We performed a randomized,double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous propofol（ 0. 5mg / kg） on the incidence of cough caused by a larger bolus of intravenous fentanyl. Patients group 1 were given fentanyl at a dosage of4 μg / kg. Group 2 received 0. 5 mg / kg propofol and 4 μg / kg fentanyl-separately. The two groups were evaluated in 0,5 and 10 second intervals following the injection of fentanyl. Results The incidence of fentanyl induced cough was 29 in placebo group,compared with10 in the propofol group. There was a significant difference in the incidence and severity of cough between group 1 and 2（ P〈0. 0001）. This study also showed that propofol could decrease cough incidence in patients with smoking habit. Conclusions Priming dose of 0. 5 mg / kg propofol one minute prior to fentanyl injection is effective in suppressing fentanyl-induced cough.

关 键 词：芬太尼 咳嗽 丙泊酚 麻醉 

分 类 号：R614[医药卫生—麻醉学]