Hetero-assembly of gold nanoparticles on a DNA origami template  

作　　者：Jie Chao Yinan Zhang Dan Zhu Bing Liu Chengjun Cui Shao Su Chunhai Fan Lianhui Wang 

机构地区：[1]Key Laboratory for Organic Electronics & Information Displays, Institute of Advanced Materials, National Syngerstic Innovation Center for Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, China [2]Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

出　　处：《Science China Chemistry》2016年第6期730-734,共5页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program of China (2012CB933301);the National Natural Science Foundation of China (21305070, 21475064);the Natural Science Foundation of Jiangsu Province (BK20130861);the Sci-tech Support Plan of Jiangsu Province (BE2014719);Science Foundation of Nanjing University of Posts and Telecommunications (213005, 214175).

摘　　要：Hetero-assembling of spherical building blocks with well-defined spatial distribution holds great significance in developing chiral nanostructures. Herein, a strategy for hetero-assembling of gold nanoparticles(Au NPs) was demonstrated using rigid bifacial DNA origami as templates. By tuning the sizes and the fixed location of Au NPs on DNA origami, right-handed and left-handed Au NPs nanostructures were respectively constructed. Gel electrophoresis indicated the formation of the DNA origami-Au NPs complex and transmission electron microscopy(TEM) visually displayed the arrangement of Au NPs in these two chiral structures. The spatial configuration and 3D geometry of Au NPs were further illustrated by the stereographic TEM with tilting angles from ?30° to 30°. This strategy provides a universal approach to construct the asymmetrical 3D geometries, which may have potential applications in biomimicking and nanophotonics.Hetero-assembling of spherical building blocks with well-defined spatial distribution holds great significance in developing chiral nanostructures. Herein, a strategy for hetero-assembling of gold nanoparticles （AuNPs） was demonstrated using rigid bifacial DNA origami as templates. By tuning the sizes and the fixed location of AuNPs on DNA origami, right-handed and left-handed AuNPs nanostructures were respectively constructed. Gel electrophoresis indicated the formation of the DNA ori- gami-AuNPs complex and transmission electron microscopy （TEM） visually displayed the arrangement of AuNPs in these two chiral structures. The spatial configuration and 3D geometry of AuNPs were further illustrated by the stereographic TEM with tilting angles from -30° to 30°. This strategy provides a universal approach to construct the asymmetrical 3D geometries, which may have potential applications in biomimicking and nanophotonics.

关 键 词：hetero-assembly DNA origami gold nanoparticles chiral structure 

分 类 号：O614.123[理学—无机化学] TB383.1[理学—化学]