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作 者:关怀[1] 郭邑[2] 郭艳杰[3] 尚丽新[4] 刘盾[1] 文竹[1]
机构地区:[1]解放军第210医院妇产科,大连116021 [2]大连市妇产医院产科,大连116033 [3]大连医科大学微生态教研室,大连116044 [4]北京军区总医院妇产科,北京100700
出 处:《发育医学电子杂志》2016年第1期37-40,共4页Journal of Developmental Medicine (Electronic Version)
摘 要:目的了解消化系统畸形发生的相关因素。方法选取经产前超声检查及引产后尸检证实为消化系统畸形的死胎38例作为观察组,选取同期足月分娩的正常新生儿190例作为对照组。对两组病例的一般情况和父母亲相关参数进行对比分析。结果观察组母亲年龄显著高于对照组(P<0.05);观察组母亲孕次和产次≥2次的占比均显著高于对照组(P<0.05);观察组父亲年龄≥40岁的百分比,以及职业接触有害因素的百分比显著高于对照组(P<0.05);观察组父亲、母亲高中文化占比显著升高,大学本科及以上学历占比显著降低(P<0.05)。结论父亲及母亲年龄、文化、母亲产次、父亲职业接触有害因素可能与消化系统畸形发生有关。Objective To investigate the influencing factors relating to development of digestive system malformation so as to provide evidences for understanding and controlling this birth defect. Method A total of 38 stillbirth diagnosed by prenatal ultrasound examination and autopsy after induced labor were selected as study group. A total of 190 term live births were selected as control group. The relevant factors including the general characteristics and parental information were studied by statistical analysis. Results Maternal age of study group was significantly higher than that of the control group(P〈0.05). The percentages of pregnancy and parity times≥2 were both significantly higher in study group than those of the control group(P〈0.05). The percentages of paternal age≥40 years and paternal exposure to occupational harmful factors were both significantly higher in study group than those of the control group(P〈0.05). There were significant differences in the level of education between the two groups(P〈0.05). Conclusions Some factors such as parental age, education, maternal parity of child, and paternal exposure to occupational harmful factors may be associsted with the development of digestive system malformation.
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