云南省德宏州成人艾滋病病毒感染者中乙型病毒性肝炎病毒合并感染研究  

Co-infection of HBV among HIV-infected adults in Dehong,Yunnan

作　　者：叶润华[1] 张玉成[2] 唐仁海[1] 杨跃诚[1] 姚仕堂[1] 王译葵 王继宝[1] 杜本丽 聂永英 杨盈波 韩文香[6] 李维美[7] 段松[1] 何纳[2] 

机构地区：[1]德宏州疾病预防控制中心,云南芒市678400 [2]复旦大学公共卫生学院流行病学教研室、公共卫生安全教育部重点实验室,上海200032 [3]芒市疾病预防控制中心,云南芒市678400 [4]盈江县疾病预防控制中心,云南盈江679300 [5]瑞丽市疾病预防控制中心,云南瑞丽678600 [6]陇川县疾病预防控制中心,云南陇川678700 [7]梁河县疾病预防控制中心,云南梁河679200

出　　处：《疾病监测》2016年第5期402-405,共4页Disease Surveillance

基　　金：国家“十二五”科技重大专项(No.2013ZX10004-906-001);国家自然科学基金(No.81373062)~~

摘　　要：目的了解云南省德宏州艾滋病病毒（HIV）感染者中乙型病毒性肝炎（乙肝）病毒（HBV）合并感染率,并分析其影响因素。方法对德宏州HIV感染者进行横断面调查,进行乙肝五项指标检测。结果在进行乙肝五项指标检测的5732例HIV感染者中,共有486例（8.5%）乙肝表面抗原（HBs Ag）阳性,2737例（47.7%）乙肝表面抗体（HBs Ab）阳性,102例（1.8%）乙肝e抗原（HBe Ag）阳性,522例（9.1%）乙肝e抗体（HBe Ab）阳性,3727例（65.0%）乙肝核心抗体（HBc Ab）阳性,90例（1.6%）感染者为乙肝＂大三阳＂（HBs Ag、HBe Ag和HBc Ab三项阳性）。多因素logistic回归分析显示,18-29岁年龄组＂大三阳＂阳性率高于50岁以上年龄组（OR=3.04,95%CI：1.30-7.15）;男性＂大三阳＂阳性率高于女性（OR=1.77,95%CI：1.06-2.95）。结论德宏州HIV感染者中存在一定比例的HBV合并感染者;不同特征HIV感染者,HBV合并感染率不同。Objective To understand the prevalence of hepatitis B virus（ HBV） infection and related risk factors among HIV-infected adults in Dehong,Yunnan province. Methods A cross-sectional study was carried out among HIV-infected adults in Dehong and serum tests were performed to detect HBV infection related markers. Results A total of 5732 HIV infected adults were included in this study,the positive rates of HBs Ag,HBs Ab,HBe Ag,HBe Ab,HBc Ab were 8. 5%,47. 7%,1. 8%,9. 1%,and 65. 0%,respectively. The positive rate of HBs Ag,HBe Ag and HBc Ab was 1. 6%,Multivariate logistic regression analysis indicated that the risk of HBV infection was higher in those aged 18- 29 years than in those aged 50 years（ OR = 3. 04,95% CI： 1. 30- 7. 15）,in males than in females（ OR = 1. 77,95% CI： 1. 06- 2. 95） among the HIV infected adults surveyed. Conclusion The co-infection of HBV was prevalent in HIV-infected adults in Dehong and related with demographic characteristics.

关 键 词：艾滋病病毒 乙型病毒性肝炎病毒 合并感染 德宏州 

分 类 号：R512.91[医药卫生—内科学] R512.62[医药卫生—临床医学]