小檗碱调脂作用机制的研究进展  

Research progress on lipid-regulating mechanism of berberine

作　　者：姜甜[1] 贾友宏[1] 李一石[1] 

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院卫生部心血管药物临床研究重点实验室临床药理中心,北京100037

出　　处：《现代药物与临床》2016年第5期727-730,共4页Drugs & Clinic

基　　金："重大新药创制"科技重大专项(2012ZX09303-008-001);2010年国家临床重点专科建设项目

摘　　要：小檗碱是从黄连等植物中提取的一种异喹啉类生物碱,作为传统的抗炎、抑菌药物在临床应用已久。近年来研究发现其具有调脂作用,可通过调节肠道菌群结构、影响胆汁酸的合成与代谢、上调低密度脂蛋白受体(LDLR)的表达、激活内脏脂肪组织相关基因的表达、升高血清脂联素的表达、激活腺苷酸活化蛋白激酶(AMPK)途径、改善胰岛素抵抗等多个作用靶点发挥调脂作用,主要针对小檗碱的调脂作用及其机制进行综述。Berberine is an isoquinoline alkaloid isolated from Coptis chinensis, and it is applied widely in clinic as a traditional anti-inflammatory and antibacterial drug for a long time. In recent years, it has been discovered that berberine still has lipid-regulating effects. Berberine plays the role of lipid-regulating by adjusting the structure of intestinal flora, influencing the synthesis and metabolism of bile acid, up-regulating the expression of low density lipoprotein receptor（LDLR）, activating the expression of visceral adipose tissue related genes, elevating the expression of adiponectin, activating AMP-activated protein kinase（AMPK） pathways, and improving insulin resistance. This paper mainly summarizes the lipid-regulating function of berberine and its mechanisms of action.

关 键 词：小檗碱 调脂作用 作用机制 

分 类 号：R286.2[医药卫生—中药学]