Copper-Mediated Deuterotrifluoromethylation of α-Diazo Esters  

作　　者：Mingyou Hu Qiqiang Xie Xinjin Li Chuanfa Ni Jinbo Hu 

机构地区：[1]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2016年第5期469-472,共4页中国化学（英文版）

摘　　要：A copper-mediated deuterotrifluoromethylation of α-diazo esters under the promotion of deuterium oxide （D20） has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethyl- ation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. More- over, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.A copper-mediated deuterotrifluoromethylation of α-diazo esters under the promotion of deuterium oxide （D20） has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethyl- ation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. More- over, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.

关 键 词：COPPER TRIFLUOROMETHYLATION DEUTERIUM diazo compounds 

分 类 号：TQ426.7[化学工程] S511.03[农业科学—作物学]