坦索罗辛联合索利那新对老年男性膀胱过度活动症患者的临床疗效及其作用机制  

Clinical Effect and Mechanism of Tamsulosin Combined with Solifenacin on Senile Male Patients with Overactive Bladder

作　　者：屈栗明[1] 李会宁[1] 刘坤龙[2] 熊贤明[1] 张晓莲[1] 

机构地区：[1]陕西省第二人民医院泌尿外科,陕西西安710005 [2]第四军医大学西京医院,陕西西安710032

出　　处：《现代生物医学进展》2016年第18期3477-3480,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(2009JQ4003)

摘　　要：目的:探究坦索罗辛联合索利那新对老年男性膀胱过度活动症患者的临床疗效及其可能的作用机制。方法:收集我院泌尿科收治的老年男性膀胱过度活动症患者100例,根据随机对照表分为对照组和试验组,各50例,2组均实施常规治疗以及对症治疗,对照组给予盐酸莫西沙星片及盐酸坦索罗辛缓释胶囊,试验组在对照组的基础上联合给予琥珀酸索利那新片。两组7天为一个治疗周期,共治疗12个周期。治疗后,对比分析两组的临床疗效、治疗前后储尿期症状评分(USPSS)、排尿期症状评分(VSS)、OABSS评分、尿液神经生长因子水平、P2X3受体表达情况以及不良反应的发生情况。结果:治疗后,与对照组相比,试验组临床总有效率较高(P<0.05),USPSS、VSS、OABSS评分较低(P<0.05),尿液神经生长因子水平及P2X3表达较低(P<0.05),两组不良反应比较,差异无统计学意义(P>0.05)。结论:坦索罗辛联合索利那新对老年男性膀胱过度活动症患者的临床疗效显著,安全性高,这可能与其显著降低尿液神经生长因子以及P2X3受体表达水平有关。Objective： To investigate the clinical therapeutic effect and mechanism of tamsulosin combined with solifenacin in the treatment of senile male patients with overactive bladder. Methods： 100 senile male patients with overactive bladder admitted in the department of urology of our hospital were selected and divided into the control group and the experimental group with 50 cases in each group. Both groups received routine treatment and symptomatic treatment. The control group was treated by moxifloxacin hydrochloride tablets and tamsulosin hydrochloride sustained release capsules and the experimental group was treated on the basis of the control group with solifenacin. The clinical curative effect, USPSS, VSS, OABSS, nerve growth factor and P2X3 receptor expressions as well as the incidence of adverse reactions were compared between two groups after treatment. Results： Compared with the control group after treatment, the clinical total effective rate was higher in the experimental group（P〈0.05）, the USPSS, VSS and OABSS levels were lower（P〈0.05）, the expressions of nerve growth factor and P2X3 receptor were lower（P〈0.05）. There was no significant difference in the incidence of adverse reactions between two groups（P〉0.05）. Conclusion： Tamsulosin combined with solifenacin had better clinical curative effect and high safety on elderly patients with overactive bladder which maight be related to the decrease of nerve growth factor and P2X3 receptor expressions.

关 键 词：坦索罗辛 索利那新 老年男性膀胱过度活动症 尿液神经生长因子 P2X3受体 

分 类 号：R694[医药卫生—泌尿科学]