应用米索前列醇治疗妊高症产后出血的疗效观察  

Effects of Misoprostol in Treating Postpartum Hemorrhage Caused by Pregnancy-induced Hypertension

作　　者：张华[1,2] 张红英[1] 袁宁霞[1] 车虹彩[1] 徐珊[1] 陈建设[2] 

机构地区：[1]陕西中医药大学第二附属医院妇产科,陕西咸阳712000 [2]河南省中医院,河南郑州450002

出　　处：《现代生物医学进展》2016年第18期3508-3510,共3页Progress in Modern Biomedicine

基　　金：河南省科技攻关项目(022463004)

摘　　要：目的:探讨应用米索前列醇对妊高症产后出血的治疗效果。方法:选取我院诊治的200例妊高症产后出血孕妇,将患者分为观察组与对照组,每组100例患者,胎儿娩出后对照组肌注催产素,观察组直肠给予米索丽列醇,按摩子宫,比较治疗后两组患者的平均出血量以及血压状况。结果:治疗前对照组和观察组平均出血量分别为(623.2±45.8)m L、(630.0±46.3)m L(P1=0.176)。治疗后,两组平均出血量分别为(486.1±24.3)m L、(313.3±23.1)m L。与治疗前相比,治疗后两组产妇的出血量均有不同减少,观察组患者少于对照组患者(P2=0.026)。对照组中重度妊高症患者的收缩压及舒张压分别为(170.1±6.7)mm Hg、(113.2±2.1)mm Hg,中度(153.6±5.1)mm Hg、(104.5±5.3)mm Hg,轻度(138.9±4.2)mm Hg、(93.2±2.0)mm Hg。观察组重度妊高症患者中以上指标分别为(169.2±6.5)mm Hg、(114.4±2.5)mm Hg,中度患者(156.2±4.8)mm Hg、(105.9±4.9)mm Hg,轻度患者(140.2±4.4)mm Hg、(90.2±4.4)mm Hg,相应病情下两组患者血压方面均无统计学差异(P3=0.87,P4=0.88,P5=0.75,P6=0.83,P7=0.64,P8=0.92)。对照组和观察组患者中不良反应发生率分别为1.0%(1/100)、2.0%(2/100),差异无统计学意义(P>0.05)。结论:米索前列醇直肠用药治疗妊高症产后出血,疗效显著、给药方便、安全性较高,值得进一步推广。Objective： To explore the effect of Misoprostol in treating postpartum hemorrhage caused by pregnancy-induced hypertension（PIH）. Methods： We selected in our hospital 200 cases of PIH pregnant women with postpartum bleeding. They were divided randomly into observation group and control group, 100 patients in each group. After fetal childbirth, patients in control group had intramuscular injection of oxytocin, while patients in observation group had Misoprostol and uterus massage. Compare the average blood loss and blood pressure after treatment between the two groups. Results： The average blood loss before treatment in control group and observation group was respectively（623.2±45.8） m L and（630.0 ± 46.3） m L, P1 = 0.176. After treatment, the average blood loss was respectively（486.1±24.3） m L and（313.3±23.1） m L in control group and observation group. Compared with before treatment,maternal blood loss after treatment was decreased in two groups. The blood loss in observation group was less than in control group（P2 =0.026）. The systolic blood pressure and diastolic blood pressure of patients in severe PIH state in control group were（170.1±6.7） mm Hg,（113.2±2.1） mm Hg, those of patients in medium state were（153.6±5.1） mm Hg,（104.5±5.3） mm Hg, and those of patients in mild state were（138.9±4.2） mm Hg,（93.2±2.0） mm Hg, respectively. The systolic blood pressure and diastolic blood pressure of patients in severe PIH state in observation group were（169.2 ±6.5） mm Hg,（114.4 ±2.5） mm Hg, those in medium state were（156.2 ±4.8） mm Hg,（105.9 ±4.9） mm Hg, and those in mild state were（140.2 ±4.4） mm Hg,（90.2 ±4.4） mm Hg, respectively. Under the corresponding condition, there were no statistical differences between two groups（P3=0.87, P4=0.88, P5=0.75, P6=0.83, P7=0.64, P8=0.92）. The incidence rates of adverse reactions in control group and observation group were respectively 1.0%（1/100） and 2.0%（2/100）, with no statistical

关 键 词：米索前列醇 妊高征 产后出血 缩宫素 

分 类 号：R714.252[医药卫生—妇产科学]