低渗与等渗造影剂对外周血管介入患者发生造影剂肾病的比较研究  

Comparative study of iso-osmolar versus low-osmolar contrast media on contrast-induced nephropathy in peripheral artery interventional therapy

作　　者：唐小斌[1] 陈忠[1] 张腾飞[1] 何楠[1] 刘丹[1] 王晓娜[1] 寇镭[1] 吴章敏[1] 刘晖[1] 王盛[1] 吴庆华[1] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所血管外科,100029

出　　处：《心肺血管病杂志》2016年第5期366-368,共3页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:对比低渗性造影剂与等渗性造影剂对外周血管介入治疗患者发生造影剂肾病(CIN)的影响。方法:入选2012年1月1日至2013年12月31日间,北京安贞医院血管外科行介入治疗的下肢缺血患者170例,随机分成低渗性造影剂组(欧乃派克)和等渗性造影剂组(威视派克),终点事件是血清肌酐升高44.2μmol/L以上或相对于基线水平升高25%的患者比例。结果:欧乃派克组(n=98)和威视派克组(n=72)发生CIN者分别为26(26.5%)及20(27.8%)例,发生率差异无统计学意义(P=0.856);且对于合并肾功能不全患者,两组CIN发生率差异无统计学意义(P=0.587)。结论:在外周血管介入治疗的下肢缺血患者中,等渗与低渗性造影剂所致CIN发生率类似,等渗性造影剂未显示优越性。Objective： To evaluate the effects of low-osmolar and iso-osmolar contrast media on contrast-induced nephropathy （CIN） in patients who underwent peripheral artery interventional therapy. Methods： 170 lower extremity Ischemia in-hospital patients admitted in vascular surgery department of Anzhen Hospital who underwent peripheral artery interventional therapy were enrolled in this study between January 1,2012 and December 31, 2013. The patients were randomized to low-osmolar contrast media （Omnipaque） or iso-osmolar contrast media （Visipaque）. The primary end point was a rise in serum creatinine of 44. 2p, mol/L or more or the serum creatinine increases 〉 25% from baseline to 48-72 hours after intervention. Results： CIN was found in 26（26. 5% ） of the Omnipaque group and 20 （27.8%） of the Visipaque group. There was no significant difference between them （ P = 0. 856 ）. Similarly, in the patients complicated with renal dysfunction, both groups again showed no significant difference in the occurrence of CIN （P = 0. 587 ）. Conclusion： In lower extremity isehemia patients who underwent peripheral artery intervention, both Visipaque and Omnipaque induced CIN equally. Iso-Osmolar contrast media was not superior to the Low-Osmolar in preventing CIN.

关 键 词：外周血管介入治疗 低渗性造影剂 等渗性造影剂 肾功能不全 造影剂肾病 

分 类 号：R54[医药卫生—心血管疾病]