星点设计-效应面法优选冠心平颗粒一步制粒工艺研究  

Study on the One-Step Pelletization Technology of Guanxinping Granule by Central Composite Design and Response Surface Method

作　　者：康小东[1,2] 张艳军[1,2] 刘俊超[1,2] 李峰[1,2] 杨绪芳[1,2] 王振中[1,2] 萧伟[1,2] 

机构地区：[1]江苏康缘药业股份有限公司，连云港 222000 [2]中药制药过程新技术国家重点实验室，连云港 222000

出　　处：《世界科学技术-中医药现代化》2016年第4期640-645,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部"重大新药创制"科技重大专项(2013ZX09402203):现代中药创新集群与数字制药技术平台;负责人:王振中

摘　　要：目的:优选冠心平颗粒一步制粒最佳成型工艺。方法:采用Plackett?Burman设计实验确定影响冠心平颗粒一步制粒的主要影响因素,然后采用Box?Behnken中心复合原理对主要影响因素设计3因素3水平实验,以颗粒合格率、休止角作为综合评价指标对试验结果进行优化,确定冠心平颗粒一步制粒最佳工艺。结果:冠心平颗粒一步制粒最佳工艺为进样速度25 r·min?1,浸膏密度1.20,进风温度90℃。结论:利用优化方案制得的颗粒与效应面模型预测值基本一致,优选的工艺稳定可行。This study aimed to optimize the molding process of Guanxinping granule（GXPG） by one-step pelletization method. Plackett-Burman experiment was designed to determine the main influence factors of one-step pelletization, while Box-Behnken central composite principle was to the orthogonal test of three factors at three different levels. The optimum method depended on comprehensive evaluation indexes such as qualified rates of particles and the angle of repose, for determining the best molding process of GXPG. As a result, the preferred parameters of molding process were as follows, the sample rate of 24 r·min-1, extract density of 1.20, and inlet air temperature at 90℃. In conclusion, the comprehensive evaluation results of one-step pelletization was close to the predicted values of response surface model, and the optimum molding process was stable and feasible for GXPG preparation.

关 键 词：冠心平颗粒 星点设计 效应面法 一步制粒 

分 类 号：R283.6[医药卫生—中药学]