康乐方治疗肝郁肾虚型勃起功能障碍的临床疗效观察  

Kangle Decoction for erectile dysfunction with liver-qi stagnation and kidney deficiency

作　　者：陈强[1,2] 朱勇[3] 曾明月[4] 杨凯[5] 黄健[6] 卞廷松[7] 王劲松[8] 曾庆琪[6,9] 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210023 [2]南京中医药大学附属江阴市中医院男科,江苏江阴214400 [3]南京中医药大学附属盐城市中医院男科,江苏盐城224001 [4]北京中医药大学临床医学院,北京100029 [5]南京中医药大学附属张家港市中医院男科,江苏张家港215030 [6]江苏省中医院男科,江苏南京210029 [7]南京中医药大学附属常州市中医院男科,江苏常州213003 [8]徐州市第一人民医院男科,江苏徐州221002 [9]江苏建康职业学院中西医结合系,江苏南京210029

出　　处：《中华男科学杂志》2016年第6期538-542,共5页National Journal of Andrology

基　　金：江苏省“六大人才高峰”项目(WS-049);江苏省中医药科技项目(LB-09064)~~

摘　　要：目的:观察康乐方治疗肝郁肾虚型勃起功能障碍(ED)的临床疗效。方法:将79例肝郁肾虚型ED患者随机分为试验组和对照组,年龄分别为(36.62±8.05)岁和(37.44±8.10)岁(P>0.05),病程分别为(18.15±6.41)个月和(17.51±6.79)个月(P>0.05)。试验组给予康乐方口服,每天1剂分2次口服;对照组给予他达拉非口服,每次10 mg,1次/2 d。两组均连续治疗8周。分别于治疗前,治疗后4周、8周和停药后4周观察每组患者的国际勃起功能指数-5评分(IIEF-5)、勃起功能障碍治疗满意度(EDITS)与简化心理和人际关系评分(SFPAIRS)。结果:试验组、对照组患者IIEF-5治疗前分别为(10.78±2.28)、(10.77±2.33)分,治疗4周后分别为(13.40±2.42)、(16.00±2.68)分,治疗8周后分别为(18.60±3.50)、(18.59±3.80)分,停药4周后分别为(17.00±3.05)、(13.95±2.61)分;治疗后IIEF-5均较治疗前明显改善(P<0.05),停药4周后,试验组IIEF-5显著高于对照组(P<0.05)。试验组、对照组患者EDITS评分治疗4周后分别为(28.88±3.31)、(28.90±3.31)分,治疗8周后分别为(29.68±3.30)、(29.13±3.32)分,停药4周后分别为(29.20±2.92)、(26.82±3.23)分;停药4周后,试验组EDITS显著高于对照组(P<0.05)。治疗后两组患者性自信指数、性自然指数和性时间顾虑指数与治疗前相比均显著改善(P<0.05);停药4周后,试验组的改善程度要明显优于对照组。结论:康乐方疗效确切、不良反应小,停药后疗效持久,因而对于肝郁肾虚型ED患者具有较高的应用价值。Objective： To observe the clinical efficacy of Kangle Decoction in the treatment of erectile dysfunction（ED） with liver-qi stagnation and kidney deficiency. Methods： A total of 79 ED patients with liver-qi stagnation and kidney deficiency were randomly assigned to an experimental group（ aged [36. 62 ± 8. 05] yr and with a disease course of [18. 15 ± 6. 41] mo） and a control group（ aged [37. 44 ± 8. 10]yr and with a disease course of [17. 51 ± 6. 79]mo）,the former treated orally with Kangle Decoction at0. 5 dose bid while the latter with Cialis at 10 mg qd alt,both for 8 weeks. Before treatment,after 4 and 8 weeks of medication,and at 4 weeks after drug withdrawal,we obtained the scores of the patients in the International Index of Erectile Function-5（ IIEF-5）,Erectile Dysfunction Inventory of Treatment Satisfaction（ EDITS）,and Short-Form Psychological and Interpersonal Relationship Scales（SF-PAIRS）,and compared the indexes between the two groups of patients. Results： The IIEF-5 score was dramatically increased in both the treatment and control groups after 4 weeks（13. 40 ± 2. 42 and 16. 00 ± 2. 68） and 8 weeks of medication（18. 60 ± 3. 50 and18. 59 ± 3. 80） and at 4 weeks after drug withdrawal（17. 00 ± 3. 05 and 13. 95 ± 2. 61） as compared with the baseline（10. 78 ± 2. 28 and 10. 77 ± 2. 33）（ P〈0. 05）,even higher in the treatment than in the control group after drug withdrawal（ P〈0. 05）. The EDITS scores in the treatment and control groups were（28. 88 ± 3. 31 and 28. 90 ± 3. 31） after 4 weeks of intervention,（29. 68 ± 3. 30 and29. 13 ± 3. 32） after 8 weeks of intervention,and（29. 20 ± 2. 92 and 26. 82 ± 3. 23） at 4 weeks after drug withdrawal,all significantly higher in the former than in the latter group after drug withdrawal（ P〈0. 05）. The sexual self-confidence score（ SSCS）,sexual spontaneity score（ SSS）,and sexual time-concern score（ STCS） were all improved in the treatment and control groups after medica

关 键 词：勃起功能障碍 康乐方 国际勃起功能指数-5评分 勃起功能障碍治疗满意度 简化心理和人际关系评分 

分 类 号：R277.5[医药卫生—中医学]