NADPH氧化酶Nox4调控非诺贝特的抗高血压心肌肥大效应  

NADPH Oxidase Nox4 Regulates the Protective Effect of Fenofribate Against Cardiac Hypertrophy

作　　者：曾泗宇[1] 周长华[2] 兰树敏[1] 卢慧勤[1] 陈燕[1] 严秋江 严鹏科[3] 刘培庆[2] 

机构地区：[1]广东省第二人民医院,广东省广州市510317 [2]中山大学,广东省广州市510000 [3]广州医科大学附属第三医院,广东省广州市510000

出　　处：《中国动脉硬化杂志》2016年第6期557-560,共4页Chinese Journal of Arteriosclerosis

基　　金：广东省自然科学基金(2015A030310076)

摘　　要：目的拟阐明NADPH氧化酶Nox4与非诺贝特抗高血压心肌肥大效应的关系。方法构建腹主动脉缩窄(abdominal aorta coarctation,AAC)诱导的高血压大鼠模型,观察非诺贝特对高血压大鼠左心室肥大的影响。结果非诺贝特可显著抑制AAC高血压大鼠左心室肥大。与假手术组比较,AAC组左心室中NADPH氧化酶Nox4蛋白和mRNA水平均显著增加;与AAC组比较,非诺贝特剂量依赖性降低AAC高血压大鼠左心室中NADPH氧化酶Nox4蛋白和mRNA水平。结论降低NADPH氧化酶Nox4表达可能是非诺贝特发挥抗高血压心肌肥大效应的重要机制。Aim To elucidate the relation between NADPH oxidase Nox4 and the protective effect of fenofribate against cardiac hypertrophy. Methods Abdominal aorta coarctation（AAC）-induced hypertensive rats were constructed to observe the effect of fenofribate on left ventricular hypertrophy. Results Fenofribate could inhibit left ventricular hypertrophy in AAC-induced hypertensive rats. Compared with sham group,the mRNA and protein levels of NADPH oxidase Nox4 were significantly elevated in left ventricular tissue of AAC group;compared with AAC group,fenofribate reduced the mRNA and protein levels of NADPH oxidase Nox4 in left ventricular tissue in a dose-dependent manner.Conclusion Reducing NADPH oxidase Nox4 expression could be a crucial mechanism of fenofribate against hypertensioninduced cardiac hypertrophy. It will provide further theoretical and experimental support for fenofribate curing hypertension- induced myocardial hypertrophy.

关 键 词：非诺贝特 心肌肥大 NADPH氧化酶Nox4 

分 类 号：R5[医药卫生—内科学]