保妇康对宫颈糜烂患者ICMI-1及炎性细胞因子表达的影响  

Effects Baofukang on the expressions of ICMI 1and inflammatory cytokines in patients with cervical erosion

作　　者：王英[1] 朱峰[1] 王家美[1] 王燕[1] 

机构地区：[1]湖北省十堰市中医医院妇产科,442000

出　　处：《河北医药》2016年第11期1621-1624,共4页Hebei Medical Journal

基　　金：湖北省自然科学基金资助项目(编号:2014CDB07312)

摘　　要：目的研究保妇康对宫颈糜烂患者ICMI-1及炎性细胞因子的表达。方法选取2014年2月至2015年2月接诊的90例急宫颈糜烂患者作为本次研究对象,按照随机数表法分为观察组和对照组。观察组采用保妇康治疗,对照组采用常规药物治疗。观察2组患者治疗前后炎性因子水平变化情况及ICMI-1mRNA和TCF-β1m PNA水平表达情况变化、病情复发情况和临床疗效。结果治疗后,2组患者炎性因子IL-1、IL-6和TNF-α均有所下降,观察组下降程度[(112.28±15.37,89.27±12.31,177.22±26.13)pg/ml]优于对照组[(121.13±18.34,95.36±14.27,188.29±25.94)pg/ml],差异有统计学意义(P<0.05);观察组ICMI-1mRNA和TCF-β1m PNA水平表达降低情况[(0.66±0.09、2.46±0.64)ng/L]明显高于对照组[(0.88±0.11、3.09±0.29)ng/L],差异有统计学意义(P<0.05);2组患者IL-1β阳性细胞都所有下降,观察组下降幅度[(119.43±2.21、0.10±0.02)ng/L]高于对照组[(126.52±3.02、0.18±0.05)ng/L],差异有统计学意义(P<0.05);观察组复发率[2.22%(1/40)]低于对照组[13.33%(6/40)],临床疗效[93.33%(42/45)]高于对照组[77.78%(35/45)],2组比较差异有统计学意义(P<0.05)。结论保妇康可以降低宫颈糜烂患者血清炎性细胞因子的含量,降低子宫组织ICMI-1mRNA和TCF-β1m PNA水平的表达,调节患者免疫功能,减轻宫颈糜烂给患者带来的危害,是治疗宫颈糜烂的有效措施。Objective To observe the effects Baofukang on the expressions of ICMI 1and inflammatory cytokines in patients with cervical erosion. Methods Ninety patients with acute cervical erosion who were treated in our hospital from February 2014 to February 2015 were enrolled in the study,who were divided into observation group and control group by means of random number table. The patients in observation group were treated by Baofukang,however,the patients in control group were treated by conventional drugs. The changes of expression levels of inflammatory cytokines,ICMI-1mRNA and TCF-β1 m PNA were observed before and after treatment for both groups,moreover,the therapeutic effects and the relapse state of disease were observed and compared between two groups. Results After treatment,the expression levels of IL-1,IL-6 and TNF-α were decreased in both groups,but the decrease degree in observation group [（ 112. 28 ± 15. 37）,（ 89. 27 ± 12. 31）,（ 177. 22 ± 26. 13） pg/ml,respectively]was superior to that in control group [（ 121. 13 ±18. 34）,（ 95. 36 ±14. 27）,（ 188. 29 ±25. 94） pg / ml,respectively]（ P〈0. 05）. The expression levels of ICMI-1mRNA and TCF-β1mRNA [（ 0. 66 ± 0. 09）,（ 2. 46 ±0. 64） ng / L,respectively] in observation group were significantly lower than those [（ 0. 88 ± 0. 11）,（ 3. 09 ± 0. 29） ng / L,respectively] in control group（ P〈0. 05）. The decrease degree of IL-1β- positive cells in observation group [（ 119. 43 ±2. 21）,（ 0. 10 ± 0. 02） ng / L,respectivey] was more obvious than that in control group [（ 126. 52 ± 3. 02）,（ 0. 18 ±0. 05） ng / L,respectively]（ P〈0. 05）. The relapse rate [2. 22%（ 1 /40） ] in observation group was significantly lower than that in control group [13. 33%（ 6 /40） ],however,the clinical efficiency[93. 33%（ 42 /45） ]in observation group was significantly higher than that [77. 78%（ 35 /45） ] in control group（ P〈0. 05）. Conclusion Baofukang can reduce serum levels of inflammator

关 键 词：保妇康 宫颈糜烂 ICMI-1 炎性细胞因子 

分 类 号：R711.3[医药卫生—妇产科学]