银掺杂介孔氧化铝抗菌剂的一步合成与表征  

One-pot Synthesis and Antimicrobial Performance of Metallic Silver-doped Mesoporous Al_2O_3 Nanoparticles

作　　者：陈华军[1] 席晓晶[1] 丁梧秀[1] 

机构地区：[1]洛阳理工学院环境工程与化学学院,洛阳471023

出　　处：《高等学校化学学报》2016年第6期1036-1041,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:51279073);河南省科技厅科技攻关计划项目(批准号:132102310367)资助~~

摘　　要：以Al(NO_3)_3·9H_2O和AgNO_3为原料,采用水热法制备了介孔氧化铝纳米粒子(Mesoporous Al_2O_3NPs)和银掺杂介孔氧化铝纳米粒子(Mesoporous Ag/Al_2O_3NPs),通过X射线衍射(XRD)、场发射扫描电子显微镜(FE-SEM)、X射线荧光光谱(XRF)、能量分散X射线衍射(EDX)和低温N2吸附-脱附等手段对产物进行了表征,通过最低抑菌浓度和抑菌圈实验研究了材料的抗菌性能.XRD分析表明在介孔Ag/Al_2O_3NPs中Al_2O_3是唯一结晶相,Ag掺杂后,介孔Ag/Al_2O_3NPs晶格常数和半高峰宽增大,晶面间距[(111),(400)和(440)面]减小.FE-SEM形貌分析表明掺杂后的介孔Ag/Al_2O_3NPs颗粒直径减小而孔径增大.EDX和XRF分析表明介孔Ag/Al_2O_3NPs中O/Al摩尔比为1.5,与Al_2O_3NPs中O/Al摩尔比相同.综合XRD和XRF分析结果认为,Ag进入介孔Al_2O_3晶格间隙形成间隙固溶体.低温N2吸附-脱附分析表明掺杂后的介孔Ag/Al_2O_3NPs比表面积、孔体积和孔径增大.曝气抗菌实验结果表明介孔Ag/Al_2O_3NPs的抗菌机理是活性氧和金属银的协同作用.介孔Ag/Al_2O_3NPs对革兰氏阴性菌(大肠杆菌)和革兰氏阳性菌(金黄色葡萄球菌)具有明显的抗菌效果,对大肠杆菌和金黄色葡萄球菌的最低抑菌浓度(MIC)均为80μg/m L,抑菌圈直径分别为26 mm和24 mm.Metallic sliver-doped mesoporous Al2O3nanoparticles（ mesoporous Ag / Al2O3NPs） were synthesized via hydrothermal method using Ag NO3 and Al（ NO3）3·9H2O as precursors. Powder X-ray diffraction（ XRD）,field-emission scanning electron microscopy（ FE-SEM）,X-ray fluorescence（ XRF）,energy dispersive spectrometry（ EDS） and N2 adsorption-desorption techniques were used to characterize mesoporous Ag /Al2O3 NPs,and the tests of minimum inhibitory concentration（ MIC） and inhibition zone were carried out to evaluate antimicrobial efficiency of mesoporous Ag / Al2O3 NPs. XRD analysis identified Al2O3 as an unique crystalline phase in mesoporous Ag / Al2O3 NPs,and the lattice parameters modified significantly after doping with silver,in the meantime,the FWHM of mesoporous Ag / Al2O3 NPs increased while the（ 111）,（ 400）and（ 440） interplanar spacing decreased. The FE-SEM images of mesoporous Al2O3 NPs and mesoporous Ag /Al2O3 NPs illustrate the diameter of mesoporous Ag / Al2O3 NPs decreased while the pore diameter increased after doping with silver. The XRF and EDX spectra of mesoporous Ag / Al2O3 NPs confirmed that the atomic ratio of O / Al was 1.5. Insightful analyses of XRD and XRF spectra of mesoporous Ag / Al2O3 NPs showed that metallic silver occupied interstitial positions of Al2O3 lattice and interstitial solid solution was achieved. N2adsorption-desorption analysis illustrates the specific surface area,pore volume and average pore diameter of mesoporous Ag / Al2O3 NPs increased significantly after doping with silver. The MIC of mesoporous Ag / Al2O3 NPs was less than 80 μg / m L against Escherichia coli and Staphylococcus aureus. The diameter of inhibition zone for mesoporous Ag / Al2O3 NPs was 26 mm against Escherichia coli and 24 mm against Staphylococcus aureus.

关 键 词：银掺杂 介孔氧化铝 革兰氏菌 抗菌性能 

分 类 号：O614[理学—无机化学]