稀土催化聚ε-癸内酯-聚丙交酯-聚乙二醇热塑性弹性体的合成及自组装  

Synthesis and Self-assembly of Thermoplastic Elastomer Poly( ε-decalactone)-Poly( L-lactide)-PEG with Rare Earth Catalyst

作　　者：王晓青[1] 凌君[1] 沈之荃[1] 

机构地区：[1]教育部高分子合成与功能构造重点实验室,浙江大学高分子科学与工程学系,杭州310027

出　　处：《高等学校化学学报》2016年第6期1182-1188,共7页Chemical Journal of Chinese Universities

基　　金：浙江省自然科学基金(批准号:LR15B040001);国家自然科学基金(批准号:21174122)资助~~

摘　　要：以三(2,6-二叔丁基-4-甲基苯氧基)镧为催化剂,1,4-丁二醇为引发剂,ε-癸内酯(ε-DL)和L-丙交酯(L-LA)为单体进行开环聚合,采用"一锅两步法"合成了3种不同比例的三嵌段聚合物(PLLA-PDL-PLLA).以L-赖氨酸二异氰酸酯(LDI)为扩链剂,将PLLA-PDL-PLLA和生物相容性好的聚乙二醇6000(PEG6000)用LDI进行偶联,制备了两亲性多嵌段聚合物(PLLA-PDL-PLLA-PEG)m.多嵌段聚合物(PLLA-PDL-PLLAPEG)m的断裂伸长率高达1200%,是一种拉伸性能较好的热塑性弹性体.由于PEG6000的亲水性,使两亲性多嵌段聚合物可以自组装形成具有较低临界胶束浓度的胶束,有望应用于生物医药领域.Three triblock copolymers PLLA-PDL-PLLA with different compositions were synthesized by lanthanum tris（ 2,6-di-tert-butyl-4-methylphenolate） [La（ OAr）3]as the catalyst and 1,4-butanediol（ BDO）as the initiator via a ＂one-pot two steps ＂ block copolymerization strategy without PDL puriflcation. With biobased L-lysine diisocyanate（ LDI） as the chain-extender,triblock copolymers were successively chain extended with biocompatible PEG6000 to produce multiblock copolymers. In tensile tests,the elongation at break of multiblock copolymers was up to 1200%,and they were good thermoplastic elastomers with an excellent mechanical property. In addition,the amphiphilic copolymers self-assembled into micelles in aqueous solution with a low critical micelle concentration（ cmc） value of 4×10-3mg / m L.

关 键 词：ε-癸内酯 稀土催化剂 多嵌段聚合物 热塑性弹性体 胶束 

分 类 号：O632[理学—高分子化学] O643[理学—化学]