2010-2015年广州市23价肺炎球菌多糖疫苗接种情况及安全性分析  

Immunization coverage and safety of the 23-valent pneumococcal polysaccharide vaccine in Guangzhou from 2010 to 2015

作　　者：陈健[1] 许建雄[1] 张春焕[1] 谭慧峰[1] 李志群[1] 

机构地区：[1]广州市疾病预防控制中心,510440

出　　处：《中华微生物学和免疫学杂志》2016年第5期380-383,共4页Chinese Journal of Microbiology and Immunology

基　　金：本课题获广东省医学科学技术研究基金项目资助（A2015036）

摘　　要：目的分析广州市23价肺炎球菌多糖疫苗（23-valent pneumococcal polysaccharide vaccine，PPV23）大规模人群应用情况及接种反应的被动监测结果，评价PPV23的使用情况及安全性。方法通过广州市生物制品管理信息系统和免疫规划信息系统获得广州市2010—2015年PPV23预防接种资料；通过疑似预防接种异常反应（adverse event following immunization，AEFI）信息管理系统，收集接种PPV23后报告的AEFI个案；采用描述性流行病学方法分析相关信息。结果2010—2015年广州市共接种PPV23 621 059剂，接种主要集中在〈10岁年龄组，占79.44%；60岁以上年龄组占9.38%。报告AEFI 243例，发生率为39.13/10万剂。一般反应199例，发生率为32.04/10万剂；异常反应25例，发生率为4.03/10万剂；偶合症16例，发生率为2.58/10万剂；心因性反应3例，发生率为0.48/10万剂；未发现罕见和极罕见不良反应。结论广州市PPV23的接种人群主要是儿童，老年人群接种率较低，被动监测数据未发现不同于其他疫苗的不良反应，PPV23的接种是安全的。Objective To analyze the immunization coverage of 23-valent pneumococcal polysaccharide vaccine （PPV23） in a large population in Guangzhou and to evaluate its safety by analyzing the adverse events following immunization （AEFI） reported to the passive surveillance system. Methods Immu- nization data of PPV23 in Guangzhou from 2010 to 2015 were collected from Information Management System of Biological Products and the Information System of Immune Programming of Guangzhou. AEFI reported to the AEFI Information System during 2010 to 2015 was collected for safety evaluation. The collected data were analyzed by using descriptive methodology. Results A total of 621 059 doses of PPV23 were prescribed in Guangzhou from 2010 to 2015. Most of the recipients were children younger than 10 years old, accounting for 79.44%. Only 9.38% of the subjects received PPV23 were older than 60 years. A total of 243 AEFI cases were reported at a rate of 39.13 cases per 100 000 doses, among which 199 cases （32.04/105） showed minor vaccine reactions, 25 cases （4.03/105） occurred adverse events, 16 cases （2.58/105） developed coupled diseases and 3 cases （0.48/105） were classified as psychogenic reactions. No rare adverse reactions were observed. Conclusion The majority of people immunized with PPV23s in Guangzhou were children, while the immunization coverage among the elderly was relatively low. PPV23 was safe for vaccination as the reported AEFI cases were similar to that of other vaccines.

关 键 词：23价肺炎球菌多糖疫苗 接种情况 疑似预防接种异常反应 安全性 

分 类 号：R186.2[医药卫生—流行病学]