介孔硅酸镁改性硫酸钙骨水泥的降解及成骨性  

Degradability and Osteogenesis of Mesoporous Magnesium Silicate Modified Calcium Sulphate Bone Cement

作　　者：陈洁[1] 董谢平[2] 刘争卉 胡兴龙[1] 魏杰[1] 

机构地区：[1]华东理工大学超细材料制备与应用教育部重点实验室,上海200237 [2]江西省人民医院骨科,南昌330006

出　　处：《无机化学学报》2016年第6期935-944,共10页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.81271705;31271031);国家科技支撑计划(No.2013BAI05B10)资助项目

摘　　要：将介孔硅酸镁(m-MS)掺杂到硫酸钙(CS)中,制备了一种新型复合骨水泥(m-MSC)。结果显示:掺入m-MS,延长了m-MSC的固化时间;提高了其降解速率;掺入m-MS可中和CS降解产生的酸性物质,缓解p H值下降。体外细胞实验显示:m-MSC能促进MC3T3-E1细胞增殖和分化;动物体内植入实验显示:m-MSC的成骨量和Ⅰ型胶原阳性表达率都显著高于CS。A novel bone cement of mesoporous magnesium silicate and calcium sulfate composite（m-MSC） was fabricated by introducing mesoporous magnesium silicate（m-MS） into calcium sulfate bone cement（CS）. The results showed that the addition of m-MS into CS prolonged the setting time and promoted the degradability of the m-MSC, and neutralized acid substance produced by CS degradation. In cell culture experiments, the result showed that the m-MSC could promote the proliferation and differentiation of MC3T3-E1 cells. In addition, the results of m-MSC histological elevation from bone trauma model revealed that massive bony tissue and Col-Ⅰformed were better than CS after 12 weeks, indicating good osteogenesis of the m-MSC.

关 键 词：介孔硅酸镁 硫酸钙 复合骨水泥 降解性 成骨性 

分 类 号：TB383[一般工业技术—材料科学与工程]