400周期夫精宫腔内人工授精临床因素的分析  

Analysis on the clinical factors of husband's sperm intrauterine insemination in 400 cycles

作　　者：何燕[1] 夏薇[1] 王维[1] 苏宁[1] 曾艳华[1] 

机构地区：[1]广州市第一人民医院生殖医学中心,广州510180

出　　处：《广州医药》2016年第3期17-20,共4页Guangzhou Medical Journal

摘　　要：目的分析影响接受夫精宫腔内人工授精（IUI）助孕患者临床妊娠率的有关因素。方法选择225例接受IUI助孕共400周期的不孕症患者,回顾分析女方年龄、治疗方案、h CG日子宫内膜厚度、IUI周期数与临床妊娠率的关系。结果女方年龄〉38岁的临床妊娠率（8.22%）低于年龄〈30岁（21.74%）和30~38岁（17.48%）,P〈0.05;促排卵方案（CC、HMG、CC＋HMG）临床妊娠率分别为19.05%、19.66%和14.71%,高于自然周期的临床妊娠率7.14%,P〈0.05;h CG日子宫内膜厚度≥8 mm组的临床妊娠率（23.56%）高于内膜〈8 mm组的临床妊娠率（13.27%）,P〈0.05;第1至第5周期的IUI临床妊娠率分别为21.30%、15.60%、9.38%、0%和0%,多次重复IUI周期数差异有统计学意义（P〈0.05）。结论女方年龄、h CG日子宫内膜厚度、治疗方案均会影响IUI的临床妊娠率,但增加IUI的治疗周期数并不能提高临床妊娠率,应综合各种因素再次评估患者的妊娠率,必要时进一步查找多次助孕失败的原因或改行IVF-ET助孕治疗。Objective To analyze the relative factors which influence the clinical pregnancy rates of patients accepted intrauterine insemination with husband’s sperm. Methods 225 cases of infertile patients accepted IUI treatment were selected,400 cycles were included and the clinical data were analyzed retrospectively. Observing the relationship between the age of women,treatment options,endometrial thickness on h CG injection day,cycles of IUI and pregnancy rates. Results The clinical pregnancy rates of women less than 30 years old（ 21. 74%） were higher than aged between 30 to 38 years old（ 17. 48%）and more than aged 38 years old（ 8. 22%）,P 〈 0. 05. The clinical pregnancy rates of ovulation induction options（ CC、HMG、CC ＋ HMG） were 19. 05%,19. 66% and 14. 71%,higher than the pregnancy rates of natural cycle 7. 14% significantly,P 〈0. 05. The pregnancy rates of the group of endometrial thickness ≥8mm on h CG injection day were 23. 56%,higher than the group of endometrial thickness 〈 8 mm 13. 27%,P 〈 0. 05. The clinical pregnancy rates of 1 to 5 cycles IUI were 21. 30%,15. 60%,9. 38%,0% and 0% respectively,the difference of repeating the IUI cycles’ number was statistical significance（ P〈 0. 05）. Conclusion The ages of women,endometrial thickness on h CG injection days and treatment options can affect the clinical pregnancy rates. Extending the number of IUI treatment cycles can not increase the pregnancy rates of IUI. All the factors should be comprehensive to assess the patient’s pregnancy rates again,to find more reasons further for the failure of assisted reproduction or turn to IVF-ET assisted reproduction treatment when it is necessary.

关 键 词：宫腔内人工授精 临床妊娠率 因素 

分 类 号：R714.8[医药卫生—妇产科学]