冠脉CT血管成像定量分析比较急性冠脉综合征和稳定冠脉冠心病患者中斑块狭窄的差异  

Comparison of quantitative plaque burden from coronary CT angiography in patients with acute coronary syndrome and stable coronary artery disease

作　　者：韦章诚[1] 罗鹰[2] 高德军[1] 彭川[1] 

机构地区：[1]攀枝花市中西医结合医院放射科,四川617000 [2]攀枝花市中西医结合医院CT室,四川617000

出　　处：《放射学实践》2016年第6期487-491,共5页Radiologic Practice

基　　金：攀枝花市科技计划项目(2012CY-S-22(7))

摘　　要：目的:探讨冠脉CT血管成像(CTA)分析急性冠脉综合征(ACS)及稳定型冠心病的斑块负荷及血管狭窄的价值。方法:选取符合要求的ACS患者及其年龄、性别均匹配的稳定型冠心病患者各40例为研究对象,分为ACS组和对照组,均行CTA检测并采用自动计算机软件包定量计算斑块及血管体积、各斑块负荷、血管狭窄及血管重建指标。结果:ACS组的非钙化斑块(NCP)负荷、总斑块负荷、狭窄程度及重建指数均明显高于对照组,差异有统计学意义(P=0.000),而各种斑块及总斑块体积、血管体积及钙化斑块(CP)负荷在两组间的差异无统计学意义(P>0.05)。NCP负荷及正性重建在ACS组中所占的比例均明显高于对照组,差异有统计学意义(P值分别为0.001,0.035,0.007),而对照组中的CP负荷则高于ACS组,差异有统计学意义(P=0.003)。结论:CTA可有效的鉴别ACS和稳定型冠心病的斑块负荷及血管狭窄等的差异,值得临床合理应用。Objective：To explore the value of coronary CT angiography（CTA）in the analysis of coronary plaque burden and coronary stenosis in patients with acute coronary syndrome（ACS）and patients with stable coronary artery disease.Methods：Forty patients with ACS who met the criteria were chosen as ACS group,and other forty patients who were ageand gender-matched to ACS group with stable coronary artery disease were chosen as control group.Coronary CTA was performed in each patient and automated software was used to quantify plaque and coronary volume,plaque burden,vessel stenosis,and coronary remodeling.Results：The noncalcified plaque（NCP）burden,total plaque burden,coronary stenosis and remodeling index of ACS group were obviously higher than that of control group,and the differences were significant（All P values were 0.000）.The differences of plaque volume,vessel volume and calcified plaque（CP）burden between these two groups were of no significance（P 〈0.05）.The proportions of NCP burden and positive vessel remodeling in ACS group were significantly higher than that in control group（Pvalues were 0.001,0.035 and 0.007,respectively）,while CP burden in control group was higher than that in ACS group,the difference was statistically significant（P=0.003）.Conclusion：Coronary CTA can effectively differentiate the differences of plaque burden and coronary stenosis between patients with ACS and stable coronary artery disease.It is worth of clinical reasonable application.

关 键 词：冠状动脉血管 冠心病 体层摄影术 X线计算机 

分 类 号：R541.4[医药卫生—心血管疾病] R816.2[医药卫生—内科学]