白花前胡甲素在臂丛神经阻滞麻醉中的应用效果观察  

Effects Observation of Praeruptorin A for Brachial Plexus Block Anesthesia

作　　者：褚丹涛 邢伟[1] 

机构地区：[1]海宁市第二人民医院,浙江海宁314000

出　　处：《中国药房》2016年第17期2376-2378,共3页China Pharmacy

摘　　要：目的:观察白花前胡甲素在上肢骨折手术患者臂丛神经阻滞麻醉中的应用效果。方法:68例上肢骨折患者按照随机数字表法分为试验组和对照组,各34例。试验组患者在臂丛神经阻滞麻醉前静脉注射0.2 mg/kg白花前胡甲素,对照组患者给予等量0.9%氯化钠注射液,比较两组患者麻醉诱导时间、疼痛反射消失时间与术后恢复时间的差异,并记录两组患者麻醉前(T0)、麻醉后即刻(T1)、麻醉后5 min(T2)、麻醉后10 min(T3)、麻醉后20 min(T4)的血流动力学指标及收缩压-心率压积(RPP)。结果:试验组患者的麻醉诱导时间、疼痛反射消失时间、术后呼吸恢复时间均显著短于对照组,差异均有统计学意义(P<0.05)。试验组患者在T2、T3、T4时刻的收缩压、舒张压、心率和平均动脉压均低于对照组,差异均有统计学意义(P<0.05)。试验组患者在T1、T2、T3、T4时刻的RPP值均显著小于对照组,差异均有统计学意义(P<0.05)。结论:上肢骨折手术臂丛神经阻滞麻醉前应用白花前胡甲素可以缩短麻醉诱导时间、疼痛反射消失时间、术后呼吸恢复时间,减轻患者血流动力学指标的波动程度。OBJECTIVE：To observe the effects of praeruptorin A for brachial plexus block anesthesia in patients receiving upper extremity fractures surgery. METHODS：68 patients receiving upper extremity fracture surgery were randomly divided into trial group and control group with 34 cases in each group. Trial group was given praeruptorin A 0.2 mg/kg intravenously before brachial plexus block anesthesia,and control group was given equivalent volume of 0.9% sodium chloride injection. The anesthesia induction time,the pain reflex disappearance time and postoperative recovery time were compared between 2 groups,and hemodynamic parameters and RPP were recorded in 2 groups before anesthesia（T0）,immediately after anesthesia（T1）,5 min after anesthesia（T2）,10 min after anesthesia（T3）,20 min after anesthesia（T4）. RESULTS：Anesthesia induction time,pain reflex disappearance time and postoperative respiratory recovery time in trial group were all significantly shorter than in control group,with statistical significance（P〈0.05）. SBP,DBP,HR and MAP of trial group were lower than those of control group at T2,T3,T4,with statistical significance（P〈0.05）. RPP of trial group was significantly lower than that of control group at T1,T2,T3 and T4,with statistical significance（P〈0.05）. CONCLUSIONS：For brachial plexus anesthesia of upper extremity fractures surgery,preoperative application of praeruptorin A can shorten anesthesia induction time,pain reflex disappearance time and postoperative respiratory recovery time,and reduce the fluctuation of hemodynamics.

关 键 词：白花前胡甲素 上肢骨折手术 臂丛神经阻滞麻醉 

分 类 号：R614[医药卫生—麻醉学]