外周血白细胞水平与原发性高血压病关系的Meta分析  

A Meta-analysis of association between peripheral blood leukocytes and essential hypertension

作　　者：田镭钢 饶绍奇[3] 梁岩[2] 

机构地区：[1]广东医学院研究生院,广东湛江524023 [2]广东省茂名市人民医院心内科,广东茂名525000 [3]广东医学院医学系统生物学研究所,广东东莞523808

出　　处：《广东医学院学报》2016年第1期4-8,共5页Journal of Guangdong Medical College

基　　金：国家自然科学基金(No.31071166;No.81373085);广东省科技计划攻关项目(No.2009A030301004);东莞市科技重点项目(No.201108101015);广东医学院基金(No.XG1001;No.JB1214;No.XZ1105;No.STIF201122)

摘　　要：目的综合评价外周血白细胞水平与高血压病关系。方法计算机检索CNKI、维普、万方、Pub Med、Embase数据库,检索时限从建库至2015年10月,纳入关于白细胞水平与高血压病关系的观察性研究,采用Stata 12.0软件进行Meta分析。结果共收集到符合要求的文献7篇,包括2 973例研究对象（病例组1 520例,对照组1 453例）。Meta分析结果显示高血压患者白细胞水平明显高于对照组（WMD=0.67,95%CI 0.50-0.85,P=0.00）。结论外周血白细胞水平是高血压重要风险因素。Objective To comprehensively evaluate the relationship between peripheral blood leukocytes and hypertension.Methods Observational studies on leukocyte and hypertension were collected in CNKI, VIP, Wan Fang, Pub Med, Embase databases from database foundation to October 2015. The meta-analysis was performed using Stata 12.0 software. ResultsSeven observational studies including 1 520 cases and 1 453 controls were retrieved. Meta-analysis showed that the leukocyte counting was significantly higher in hypertension group than in control group（WMD=0.67, 95%CI 0.50-0.85, P=0.00）. Conclusion Number of leukocytes from peripheral blood is an important risk factor for hypertension.

关 键 词：白细胞 高血压病 META分析 

分 类 号：R544.1[医药卫生—心血管疾病]