LEEP联合艾立舒(EaLeSu)治疗CINⅡ～Ⅲ合并HPV感染临床效果  

Clinical Effect of EaLeSu on CIN Ⅱ～Ⅲ Patients with HPV Infection Treated with LEEP

作　　者：韩瑞英[1,2] 马秀君[1,2] 王安杰[1,2] 马丽霞[1,2] 年英华[3] 

机构地区：[1]河北医科大学附属邢台市人民医院妇科 [2]临西县医院妇产科,河北邢台054031 [3]昆明医科大学第三附属医院云南省肿瘤医超声科,云南昆明650118

出　　处：《昆明医科大学学报》2016年第5期104-106,共3页Journal of Kunming Medical University

基　　金：河北省科技基金资助项目(20131075)

摘　　要：目的探讨艾立舒在宫颈电环切除术（LEEP）治疗宫颈宫颈上皮内瘤变（CINⅡ-Ⅲ）合并HPV感染中的临床效果.方法将165例CINⅡ-Ⅲ合并HPV感染行LEEP手术患者随机分为观察组83例和对照组82例.观察组术后即在宫颈创面推注艾立舒1支,术后第1天开始,每日阴道放置艾立舒2支,连续8 d;对照组术后常规用碘伏棉球擦洗宫颈创面换药.观察术后1周、2周、3周、4周阴道排液时间、出血率、宫颈创面修复及术后6个月宫颈HPV DNA感染情况等.结果 2组术后出血率、阴道排液时间、宫颈创面修复及HPV DNA比较,差异有统计学意义（P〈0.05）.结论 LEEP联合艾立舒治疗CINⅡ~Ⅲ合并HPV感染疗效确切.Objective To investigate the clinical effect of EaLeSu on cervical intraepithelial neoplasia（CINⅡ-Ⅲ） patients with HPV infection treated with loop electrosurgical excision procedure（LEEP）. Methods 165 cases of CIN Ⅱ- Ⅲ patients with HPV infection who underwent LEEP operation were randomly divided into observation group（n=83） and control group（n=82）. In the observation group,patients were given a piece of Ea Le Su in cervical wound at once in postoperative and two vaginal Ea Le Su per day from the first postoperative day for eight consecutive days. The patients in the control group were treated with routine debridement and wound dressing with iodine. We observed the vaginal drainage times within 4 weeks after operative, bleeding rate, cervical wound repair, and cervical HPV DNA infection after 6 months. Results There were significant differences in the bleeding rate, vaginal drainage time, cervical wound repair and HPV DNA infection between the two groups（P 〈 0.05）.Conclusion Ea Le Su showed a definite effect on cervical intraepithelial neoplasia（CIN Ⅱ-Ⅲ） patients with HPV infection treated with LEEP.

关 键 词：人乳头瘤病毒 上皮内瘤变 宫颈电环切除术 

分 类 号：R711.32[医药卫生—妇产科学]