雾化吸入糖皮质激素与H1受体阻滞剂治疗小儿哮喘相关指标的变化  

Atomizing Inhaled Corticosteroids and H1 Receptor Blockers Changes for the Treatment of Infantile Asthma Related Indicators

作　　者：王翠华[1] 

机构地区：[1]菏泽市立医院儿科,山东菏泽274031

出　　处：《菏泽医学专科学校学报》2016年第2期20-23,共4页Journal of Heze Medical College

摘　　要：目的探讨雾化吸入糖皮质激素与H1受体阻滞剂治疗小儿哮喘的疗效。方法哮喘患儿80例,随机编号法分为两组,对照组40例在常规治疗的基础上采用糖皮质激素(布地奈德)雾化吸入。观察组在对照组的基础上采用H1受体阻滞剂(西替利嗪),5 d为1个疗程,1个疗程结束后进行数据处理。所数据采用方差分析、t检验和2检验。结果两组治疗后的临床症状、肺功能以及炎性因子均较治疗前显著改善,治疗前后比较,P<0.05,有显著性差异。治疗后观察组与对照组比较,P<0.05,有显著性差异。两组不良反应比较,P>0.05,无显著性差异。结论雾化吸入糖皮质激素与H1受体阻滞剂能够显著改善哮喘患儿的临床症状和肺功能,降低炎性因子水平,且不良反应少。Objective To investigate the atomizing inhaled corticosteroids and H1 receptor blockers in the treatment of infantile asthma. Methods 80 cases children with asthma, random number method is divided into two groups,control group 40 cases on the basis of conventional treatment using glucocorticoid budesonide aerosol inhalation. On the basis of the observation group in the control group using the H1 receptor blockers（cetirizine）, 5 d for a period of treatment, one end of the course of data processing. Data by using analysis of variance, t test and X-2 test. Results Two groups after treatment of clinical symptoms, pulmonary function and inflammatory factor was improved significantly, the comparison before and after treatment, P〈0.05, there is significant difference. The observation group after treatment compared with control group, P〈0.05, there is significant difference. Adverse reactions to compare two groups, P〈0.05, no significant differences. Conclusion Atomization inhalation corticosteroids and H1 receptor blockers can significantly improve the clinical symptoms and lung function in children with asthma, lower levels of inflammatory cytokines, and less adverse reaction.

关 键 词：雾化吸入/投药和剂量 糖皮质激素/治疗应用 H_1受体阻滞剂/治疗应用 支气管哮喘/治疗 

分 类 号：R562.25[医药卫生—呼吸系统]