丹参注射液联合环磷腺苷葡胺治疗肺心病的疗效及对血流变学的影响  

The efficacy of Danshen injection combined with adenosine cyclophosphamide meglumine in treatment pulmonary heart disease and its effect on blood rheology

作　　者：孙卫东[1] 罗璨璟[1] 邓翠东[1] 吴俊才[1] 

机构地区：[1]自贡市第四人民医院老年科,四川自贡643000

出　　处：《西部医学》2016年第6期845-848,共4页Medical Journal of West China

基　　金：四川省科技厅科研项目(2010FZ0102)

摘　　要：目的探讨丹参注射液联合环磷腺苷葡胺治疗肺心病的疗效及对血流变学的影响。方法将2014年3月~2015年3月就诊的66例肺心病患者,采用简单数字表法随机分为试验组和对照组各33例,两组患者均采用吸氧、抗感染、扩张支气管、利尿、纠正电解质平衡紊乱等常规治疗,其中试验组患者在此基础上应用丹参注射液联合环磷腺苷葡胺静滴,比较两组患者临床疗效,治疗前后两组患者肺功能指标FEV1（第一秒用力呼气容积）、FVC（用力肺活量）、FEV1/FVC（两值占用比）、血液流变学指标（高切全血粘度、低切全血粘度、血浆粘度和纤维蛋白原含量）变化以及心功能改善情况和用药不良反应情况。结果试验组总有效率为93.94%（31/33例）,高于对照组的总有效率（75.76%,25/33例）,组间差异有统计学意义（χ^2=4.24,P=0.0394）;两组患者治疗前FEV1、FVC和FEV1/FVC肺功能指标比较,差异无统计学意义（均P〉0.05）,治疗后均显著升高（P〈0.05）,且试验组患者的升高程度优于对照组,差异均有统计学意义（均P〈0.05）;两组患者治疗后心功能均有改善,差异有统计学意义,且试验组患者治疗后的心功能改善情况明显优于对照组,差异有统计学意义（χ^2=12.0248,P=0.0024）;两组患者治疗前高切全血粘度、低切全血粘度、血浆粘度和纤维蛋白原各血液流变学指标比较,差异均无统计学意义（均P〉0.05）,治疗后均显著降低（均P〈0.05）,且试验组患者治疗后各项指标的降低程度明显优于对照组患者（P〈0.05）;两组患者用药期间均未出现不良发应。结论丹参注射液联合环磷腺苷葡胺治疗肺心病的疗效显著,可以有效提高患者的肺功能和心功能,改善血液流变学指标,且用药安全,适合临床长期推广应用。Objective To analyze the efficacy of Danshen injection combined with cyclophosphamide adenosine meglumine in treatment pulmonary heart disease and its effect on blood rheology.Methods 66 patients with pulmonary heart disease selected from March 2014 to March 2015 in our hospital were randomly divided into the experimental group（33 cases）control group（33 cases）.The two groups were treated with oxygen,antibiotics,bronchodilators,diuresis,correcting electrolyte balance treatment.The experimental group was treated with Danshen injection and cyclophosphamide adenosine meglumine,additionally.The clinical efficacy,pulmonary function {FEV1（forced expiratory volume in one second）,FVC（forced vital capacity）,FEV1/FVC（ratio of two values occupancy）},hemorheology（high shear whole blood viscosity,low shear whole blood viscosity,plasma viscosity and fibrinogen）changes and cardiac function improvement and adverse drug reactions were observed.Results The total effective rate of the experimental group（93.94%）was higher than that of the control group（75.76%）,and the difference was statistically significant（χ^2=4.24,P=0.0394）.FEV1,FVC and FEV1/FVC of the two groups before treatment were not statistically significant（P〈0.05）different that after treatment（P〈0.05）.The increased degree of patients in the test group were better than those of the control group（P〈0.05）.The heart function of the two groups improved after treatment（P〈0.05）.The improvement of heart function of experimental group were better than that of the control group（χ^2=12.0248,P=0.0024）.The whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,fibrinogen and hemorheology decreased after treatment（P〈0.05）.The improvements of them after treatment of experimental group were more seriously reduced than that of the control group patients（P〈0.05）.There were no bad medication during the treatment of the two groups.Conclusions Danshen injection combined with cyclophosphamid

关 键 词：丹参注射液 环磷腺苷葡胺 肺心病 血流变学 

分 类 号：R541.5[医药卫生—心血管疾病]