77例拉莫三嗪不良反应的文献分析  

Literature Review of 77 Cases of Adverse Drug Reactions Induced by Lamotrigine

作　　者：何心[1] 张永[1] 徐进[1] 许静[1] 

机构地区：[1]南京医科大学附属南京儿童医院药学部,江苏南京210008

出　　处：《中国药物警戒》2016年第5期303-305,308,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨拉莫三嗪致不良反应的一般规律和临床特点,为临床合理用药提供参考。方法检索1994~2014年间国内外医药期刊公开报道的拉莫三嗪致不良反应的个案报道,并进行统计分析。结果个案报道共检索到77例,Stevens-Johnson综合征死亡3例,急性肝衰竭死亡1例。不良反应主要以皮肤损害为主,其所致不良反应可能与患者性别、年龄、联合用药等有一定的关联。结论临床应用拉莫三嗪时,应关注患者性别、年龄、药物相互作用及给药剂量,高度重视其所致的不良反应,确保用药安全。Objective To investigate the general rules of lamotrigine（LTG）-related adverse drug reactions（ADRs） and clinical characteristics, and to promote rational use of LTG. Methods Literatures of LTG-induced ADRs reported in domestic and overseas pharmaceutical journals from 1994 to 2014 were retrieved and analyzed. Results 77 cases were collected in which three patients died for Stevens-John son syndrome and one for acute liver failure. Most of LTG-related ADRs were skin lesions which may relate to the gender, age and combination use of drugs. Conclusion It is recommended to consider the gender, age, dose, and combination use of drugs when using LTG. More attention should be paid to LTG-related ADRs to promote its rational use.

关 键 词：拉莫三嗪 药品不良反应 文献分析 

分 类 号：R994.11[医药卫生—毒理学]