泽桂癃爽胶囊联合克拉霉素缓释片治疗老年前列腺炎的临床疗效及对前列腺液炎性因子的影响  

Efficacy of Zegui Longshuang capsules combined with clarithromycin sustained release tablets for elderly prostatitis and impact on inflammatory cytokines in prostatic fluid

作　　者：何钢[1] 

机构地区：[1]武汉市第一医院泌尿外科,湖北武汉430022

出　　处：《中国生化药物杂志》2016年第4期135-137,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨泽桂癃爽胶囊联合克拉霉素缓释片对老年前列腺炎患者前列腺液IL-2、IL-6及IL-1β水平影响。方法选取慢性前列腺炎老年患者116例,按随机数字表法分为2组,对照组58例予以克拉霉素缓释片治疗,研究组58例予以泽桂癃爽胶囊联合克拉霉素缓释片治疗,疗程30 d,对比2组患者治疗前后前列腺液(expressed prostatic secretions,EPS)白细胞(WBS)、卵磷脂小体(small particle of lecithin,SPL)及IL-1β、IL-6、IL-2变化状况,同时对比临床疗效及并发症状况。结果对照组临床有效率74.14%低于研究组临床有效率89.66%(P<0.05);研究组治疗后前列腺液白细胞及卵磷脂小体改善状况优于对照组(P<0.05),研究组治疗后列腺液IL-1β、IL-6、IL-2和TNF-α水平低于对照组(P<0.05),2组间总不良反应率差异无统计学意义。结论泽桂癃爽胶囊联合克拉霉素缓释片能显著降低老年前列腺炎患者前列腺液IL-2、IL-6及IL-1β水平,效果显著。Objective To investigate the effects of IL-2,IL-6 and IL-1β levels in prostatic fluid by Zegui Longshuang capsules combined with clarithromythin sustained release tablets in elderly patients with prostatitis. Methods A total of 116 elderly patients with chronic prostatitis from our hospital were collected,patients or family members signed an agreement,and randomly divided into experimental group and control group with 58 cases in each group. Patients in control group were treated by clarithromycin sustained-release tablets,patients in the experiment group were treated by Zegui Longshuang capsules combined with clarithromycin sustained release tablets,treated for 30 d,compared the prostatic fluid leucocyte,lecithin bodies and IL-1β,IL-6,IL-2 changed of the two groups patients before and after treatment. At the same time,compared clinical efficacy and complications.Results The clinical effective rate of the control group 74. 14% was lower than the experiment group 89. 66%,with statistical significance（ P〈0. 05）;the prostatic fluid leucocyte and lecithin bodies of the experiment group improved situations were better than the control group after treatment,the IL-1β,IL-6,IL-2 and TNF- a levels in prostatic fluid of the experiment group were lower than the control group,with statistical significance（ P〈0. 05）,and the total adverse reactions rate of the two groups with no difference. Conclusion Zegui Longshuang capsules combine with clarithromycin sustain release tablets can significantly reduce the prostatic fluid of IL-2,IL-6 and IL-1β levels in elderly prostatitis,the effect is obvious.

关 键 词：泽桂癃爽胶囊 克拉霉素缓释片 老年前列腺炎 IL-2 IL-6 IL-1Β 

分 类 号：R697.3[医药卫生—泌尿科学]