多巴胺联合米力农对老年顽固性心力衰竭临床疗效、心功能和N-末端B型利钠肽前体水平的影响  

Efficacy of milrinone combined with dopamine in the treatment of elderly patients with refractory heart failure and the influence of levels of cardiac function and N-terminal B-type natriuretic peptide precursor

作　　者：史明娟[1] 於华敏[1] 何海英[1] 叶莉[1] 

机构地区：[1]杭州市余杭区第一人民医院心血管内科,浙江杭州311100

出　　处：《中国生化药物杂志》2016年第4期164-166,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的对顽固性老年心力衰竭患者实施多巴胺联合米力农治疗后对其N-末端B型利钠肽前体水平与心功能的影响进行分析探究。方法选取接受治疗的顽固性老年心力衰竭患者80例,根据数字表法将患者随机分成对照组与试验组,对照组给予常规药物治疗,试验组在对照组基础上给予多巴胺+米力农治疗,分析对比2组的临床治疗效果、N-末端B型利钠肽前体水平(NT-proBNP)与心功能情况。结果试验组的总有效率(95.00%)高于对照组(70.00%),差异有统计学意义(P<0.05)。试验组患者的NT-proBNP、LVEDD、LVEF明显优于对照组患者,差异有统计学意义(P<0.05)。结论顽固性老年心力衰竭患者实施多巴胺联合米力农治疗后效果显著,有利于缓解患者NT-proBNP水平,促进心功能的恢复。Objective To analyze and investigate dopamine combined with milrinone treatment effect on elderly patients with intractable heart failure and N-terminal B-type natriuretic peptide level and cardiac function. Methods 80 cases of elderly patients with heart failure according to the number table method randomly divided into two groups： control group and experimental group,and control group was given conventional drugs. The patients in experimental group were received dopamine ＋ Milrinone on the basis of control group. Clinical efficacy,N-terminal pro-B-type natriuretic peptide levels（ NT pro BNP） and heart function condition between two groups are compared and analyzed. Results The total effective rate of experimental group（ 95. 00%） was higher than that of control group（ 70. 00%）（ P〈0. 05）. NT-pro BNP（ 2013. 31 ± 295. 84） ng / L、LVEDD（ 61. 48 ±10. 11） mm、LVEF（ 59. 69 ± 8. 44） % in the experimental group was significantly better than the control group（ P〈0. 05）. Conclusion Dopamine combined with milrinone in the treatment of elderly patients with intractable heart failure is remarkable,can relieve the level of NT pro BNP,and promote the recovery of cardiac function.

关 键 词：顽固性心力衰竭 多巴胺 米力农 NT-PROBNP 心功能 

分 类 号：R541[医药卫生—心血管疾病]